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基于材料的正反馈回路的合成生物学启发式实现的表征

Characterization of the synthetic biology-inspired implementation of a materials-based positive feedback loop.

作者信息

Wagner Hanna J, Engesser Raphael, Ermes Kathrin, Geraths Christian, Timmer Jens, Weber Wilfried

机构信息

Faculty of Biology, University of Freiburg, Schänzlestrasse 1, 79104 Freiburg, Germany.

Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Albertstrasse 19a, 79100 Freiburg, Germany.

出版信息

Data Brief. 2018 May 18;19:665-677. doi: 10.1016/j.dib.2018.05.074. eCollection 2018 Aug.

Abstract

The translation of engineering designs to materials sciences by means of synthetic biological tools represents a novel concept for the development of information-processing materials systems. Here, we provide data on the mathematical model-guided implementation of a biomaterials-based positive feedback loop for the detection of proteolytic activities. Furthermore, we present data on an extended system design for the detection of the antibiotic novobiocin. This work is related to the research article "Synthetic biology-inspired design of signal-amplifying materials systems" (Wagner et al., 2018) [1].

摘要

借助合成生物学工具将工程设计转化为材料科学,这代表了一种用于开发信息处理材料系统的新颖概念。在此,我们提供了关于基于生物材料的正反馈回路在数学模型引导下用于检测蛋白水解活性的实施数据。此外,我们展示了关于用于检测抗生素新生霉素的扩展系统设计的数据。这项工作与研究文章《受合成生物学启发的信号放大材料系统设计》(瓦格纳等人,2018年)[1]相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/788d/5997908/3c965efaf7a4/gr1.jpg

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