Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Rua Arquiteto Lobão Vital, 172, 4200-374, Porto, Portugal.
World J Microbiol Biotechnol. 2018 Jun 13;34(7):93. doi: 10.1007/s11274-018-2471-2.
Over the years the body of work relating chitosan and its possible skin-related applications has grown, showing that chitosan is active both as a free compound and as a functional finishing of textiles. As a free molecule chitosan proved itself to be an attractive option as it is biocompatible and has a demonstrated biological activity (e.g. growth inhibition or adhesion inhibition) upon multiple skin pathogens, even upon multidrug resistant species. Furthermore, chitosan has wound healing accelerating properties, which make it a prime candidate for possible control of skin related infections. Almost inconspicuously, textiles have been one the main lines of defense of the skin against foreign threats, acting as a physical barrier to microbial colonization and infection. With the advent of textile functionalization specially designed textiles with enhanced protective characteristics, such as antimicrobial capacity, have come to the forefront. Chitosan functionalized textiles have been shown to be effective inhibitors of microbial growth with even invasive multidrug resistant species, as MRSA, being inhibited. Therefore, chitosan and chitosan functionalized textiles present themselves as both an interesting alternative to traditional antibiotics and as a possible means to enhance current treatment strategies.
多年来，与壳聚糖及其可能的皮肤相关应用相关的研究不断增加，表明壳聚糖作为游离化合物和纺织品的功能整理剂都具有活性。作为一种游离分子，壳聚糖本身就是一种有吸引力的选择，因为它具有生物相容性，并对多种皮肤病原体具有明显的生物活性（例如生长抑制或粘附抑制），甚至对多药耐药物种也是如此。此外，壳聚糖具有促进伤口愈合的特性，使其成为控制皮肤相关感染的主要候选药物。几乎不引人注意的是，纺织品一直是皮肤抵御外来威胁的主要防线之一，作为微生物定植和感染的物理屏障。随着纺织功能化的出现，具有增强保护特性的专门设计的纺织品，如抗菌能力，已经成为前沿。壳聚糖功能化纺织品已被证明是抑制微生物生长的有效抑制剂，甚至对侵袭性多药耐药物种如 MRSA 也有抑制作用。因此，壳聚糖和壳聚糖功能化纺织品不仅是传统抗生素的有趣替代品，也是增强现有治疗策略的一种可能手段。
