Schulz G, Missal O
Z Erkr Atmungsorgane. 1985;164(2):155-61.
In 100 patients with histologically confirmed bronchogenic carcinoma, the reliability of serum aldolase determination as screening test for metastases in the liver has been investigated. Demonstration respectively exclusion of liver metastases was done by laparoscopy or occasionally by autopsy. In contrast to previous results, with the presently used, more reliable technique, the results were less satisfactory. True positive aldolase values as indicators of presence of liver metastases were observed in 72,7 percent of patients carrying those. In cases of chronic liver damage of other etiology, in general no elevated aldolase values were observed. The aldolase activity correlated with the amount of tumor tissue in the liver. An improvement of the enzymatic screening might be expected from additional determination of enzymes indicating cholostasis or from determination of liver-specific aldolase isoenzyme.
在100例经组织学确诊的支气管源性癌患者中，研究了血清醛缩酶测定作为肝脏转移筛查试验的可靠性。通过腹腔镜检查或偶尔通过尸检来证实或排除肝转移。与先前的结果相反，采用目前更可靠的技术，结果却不那么令人满意。在有肝转移的患者中，72.7%观察到醛缩酶值呈真阳性，可作为肝转移存在的指标。在其他病因引起的慢性肝损伤病例中，一般未观察到醛缩酶值升高。醛缩酶活性与肝脏中肿瘤组织的数量相关。通过额外测定指示胆汁淤积的酶或测定肝脏特异性醛缩酶同工酶，有望改进酶学筛查。
