Ho K L
Acta Neuropathol. 1985;66(2):117-26. doi: 10.1007/BF00688686.
The endothelial cells of three cases of cerebellar capillary hemangioblastoma were studied by means of electron microscopy. Crystalloid bodies, not previously described in the vessels of the central nervous system (CNS), were found in 5%-10% of the endothelial cells, more often in the capillaries with small irregular lumens. They were not observed in the pericytes or stromal cells. They were round to polygonal, 0.5-1.0 micron in size and composed of substructural units of parallel thick and thin electron-dense lines with a periodicity of 180-220 A. They coexisted occasionally with Weibel-Palade bodies but shared no structural correlation with them. The nature and significance of these crystalloid bodies are as yet unknown. Their close association with pinocytic vesicles suggests that the substructural crystalline might be the result of reconstruction of absorbed material from either the vascular lumen or the interstitium. Their subsequent development, associated with lysosomal activity, into intracytoplasmic dense bodies is postulated. Since crystalloid bodies were found only in endothelial cells, particularly those active in proliferation, they may play a pathophysiologic role in relation to angiogenesis.
通过电子显微镜对3例小脑毛细血管型血管母细胞瘤的内皮细胞进行了研究。在5%-10%的内皮细胞中发现了中枢神经系统（CNS）血管中此前未描述过的晶体样小体，在管腔小且不规则的毛细血管中更常见。在周细胞或基质细胞中未观察到它们。它们呈圆形至多边形，大小为0.5-1.0微米，由平行的粗细电子致密线组成的亚结构单元构成，周期为180-220埃。它们偶尔与魏尔-帕拉德小体共存，但与它们没有结构关联。这些晶体样小体的性质和意义尚不清楚。它们与吞饮小泡的密切关联表明，亚结构晶体可能是从血管腔或间质中吸收的物质重构的结果。推测它们随后会与溶酶体活性相关联，发展为胞质致密小体。由于晶体样小体仅在内皮细胞中发现，尤其是那些增殖活跃的内皮细胞，它们可能在血管生成方面发挥病理生理作用。
