Ho K L
Department of Pathology, Henry Ford Hospital, Detroit, MI 48202.
Acta Neuropathol. 1987;74(4):345-53. doi: 10.1007/BF00687211.
Concentric lamellar bodies of endoplasmic reticulum (CLB) were found in the stromal cells of all five cases of cerebellar capillary hemangioblastoma studied ultrastructurally. CLB were often present in the stromal cells with voluminous loose cytoplasm, particularly those close to the capillaries. They were rarely seen in small stromal cells with abundant organelles and stromal cells distended by large lipid droplets. Small lipid droplets were usually present in the center or in the vicinity of CLB. Vesiculation and vacuolization of the lamellar arrays of CLB were common. Some vacuolized CLB were transformed into large, varying-shaped, multilocular bodies. Some stromal cells were markedly distended by numerous large vacuoles derived from CLB. Granulo-fibrillary material was frequently present in the vacuolized lamellae. Discharge of vacuoles into the interstitial space was observed. It is suggested that CLB is one of the characteristic ultrastructural features of the stromal cells. They may represent a special type of hyperplasia of the endoplasmic reticulum, but their functional significance is not known.
在对五例小脑毛细血管性血管母细胞瘤进行超微结构研究时，在内质网的同心层状小体（CLB）在所有病例的基质细胞中均有发现。CLB常出现在具有大量疏松细胞质的基质细胞中，尤其是那些靠近毛细血管的细胞。在具有丰富细胞器的小基质细胞以及被大脂滴扩张的基质细胞中很少见到。小脂滴通常存在于CLB的中心或其附近。CLB的层状排列出现囊泡化和空泡化很常见。一些空泡化的CLB转化为大的、形状各异的多泡体。一些基质细胞被源自CLB的大量大空泡明显扩张。颗粒状纤维物质经常出现在空泡化的板层中。观察到空泡排放到间质空间。提示CLB是基质细胞的特征性超微结构特征之一。它们可能代表内质网的一种特殊类型的增生，但其功能意义尚不清楚。
