Seyama S, Ohta M, Nishio S, Matsushima T, Kitamura K
Acta Pathol Jpn. 1982 May;32(3):399-413. doi: 10.1111/j.1440-1827.1982.tb01397.x.
Five capillary hemangioblastomas exhibiting a range of histologic variations common to this tumor were studied using electron microscopy. The capillary hemangioblastoma were composed commonly of three cell lines -- stromal cells, endothelial cells and pericytes. In addition, extramedullary hematopoietic foci were seen in the tissue of one case. We regarded all these cellular elements as neoplastic components. The interconvertibility among them was not confirmed. The capillary hemangioblastomas were highly organized by those multiple cell lines. The histologic pattern of growth was arbitrarily subgrouped into stromal cell prominent type and capillary prominent type. Intermediate features between the two types were observed. These different types would depend on relative proportions and the degree of maturity of the constituting cell elements. From the histogenetic point of view, we considered capillary hemangioblastomas as being a hamartomatous tumor.
运用电子显微镜对五例呈现出该肿瘤常见一系列组织学变异的毛细血管型血管母细胞瘤进行了研究。毛细血管型血管母细胞瘤通常由三种细胞系组成——基质细胞、内皮细胞和周细胞。此外，在一例患者的组织中发现了髓外造血灶。我们将所有这些细胞成分视为肿瘤性成分。未证实它们之间存在相互转化。毛细血管型血管母细胞瘤由这些多种细胞系高度组织化。生长的组织学模式被任意分为基质细胞突出型和毛细血管突出型。观察到两种类型之间的中间特征。这些不同类型将取决于构成细胞成分的相对比例和成熟程度。从组织发生学角度来看，我们认为毛细血管型血管母细胞瘤是一种错构瘤性肿瘤。
