Dougherty Michael P, Dolitsky Shelley, Chattopadhyay Rhea, Sauer Mark V
Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
Curr Opin Obstet Gynecol. 2018 Aug;30(4):217-222. doi: 10.1097/GCO.0000000000000467.
The present study briefly reviews the history of mitochondrial replacement therapy (MRT); however, the focus is on recent advancements and future directions of the field. Specifically addressing societal and legal concerns and advances in MRT.
There continue to be new ethical debates surrounding MRT. In addition, there have been advancements in MRT techniques which could improve potential outcomes. Furthermore, advances in genetics continue to provide alternative approaches to treatment of many diseases, including alternatives to MRT.
MRT may be beneficial to eradicate a severely debilitating and often fatal disease. Despite significant supporting safety and efficacy, there are still many social and legal barriers to instituting MRT to clinical practice.
本研究简要回顾了线粒体替代疗法（MRT）的历史；然而，重点是该领域的最新进展和未来方向。特别讨论了社会和法律问题以及MRT的进展。
围绕MRT仍有新的伦理辩论。此外，MRT技术有了进展，这可能会改善潜在结果。此外，遗传学的进展继续为许多疾病的治疗提供替代方法，包括MRT的替代方法。
MRT可能有助于根除一种严重致残且往往致命的疾病。尽管有大量支持其安全性和有效性的证据，但将MRT应用于临床实践仍存在许多社会和法律障碍。
