J Med Ethics. 2018 Dec;44(12):825-829. doi: 10.1136/medethics-2017-104661. Epub 2018 Jul 12.
Mitochondrial replacement therapy (MRT) requires oocytes of women whose mitochondrial DNA will be transmitted to resultant children. These techniques are scientifically, ethically and socially controversial; it is likely that some women who donate their oocytes for general in vitro fertilisation usage would nevertheless oppose their genetic material being used in MRT. The possibility of oocytes being used in MRT is therefore relevant to oocyte donation and should be included in the consent process when applicable. In present circumstances (especially because MRT is still an emerging technique), specific consent should be obtained. However, once MRT becomes more routine, such consent could be incorporated into the general consent process for oocyte donation. The reported lack of proper consent for MRT from the oocyte donor in the first baby born via the technique is an ethical failing and should be corrected in any future practice of MRT.
线粒体替换疗法（MRT）需要女性的卵子，这些女性的线粒体 DNA 将被传递给新生儿。这些技术在科学、伦理和社会方面存在争议；一些捐赠卵子用于普通体外受精的女性可能会反对将其遗传物质用于 MRT。因此，MRT 中使用卵子的可能性与卵子捐赠有关，在适用的情况下，应将其包含在同意过程中。在目前的情况下（特别是因为 MRT 仍然是一项新兴技术），应该获得特定的同意。然而，一旦 MRT 变得更加常规，这种同意就可以纳入卵子捐赠的一般同意过程。据报道，首例通过该技术出生的婴儿的卵子供体在 MRT 方面没有得到适当的同意，这是一个伦理失败，应该在任何未来的 MRT 实践中得到纠正。
