Freitag Nils, Weber Pia Deborah, Sanders Tanja Christiane, Schulz Holger, Bloch Wilhelm, Schumann Moritz
Clinical Exercise Science, Department of Sport and Health Sciences, University of Potsdam Department of Molecular and Cellular Sport Medicine Department of Preventive and Rehabilitative Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne Clinical Centre for Oncological and Hematological Medicine Frechen, Germany.
Medicine (Baltimore). 2018 Jun;97(24):e11068. doi: 10.1097/MD.0000000000011068.
We conducted a case study to examine the feasibility and safety of high-intensity interval training (HIIT) with increased inspired oxygen content in a colon cancer patient undergoing chemotherapy. A secondary purpose was to investigate the effects of such training regimen on physical functioning.
A female patient (51 years; 49.1 kg; 1.65 m; tumor stage: pT3, pN2a (5/29), pM1a (HEP), L0, V0, R0) performed 8 sessions of HIIT (5 × 3 minutes at 90% of Wmax, separated by 2 minutes at 45% Wmax) with an increased inspired oxygen fraction of 30%. Patient safety, training adherence, cardiorespiratory fitness (peak oxygen uptake and maximal power output during an incremental cycle ergometer test), autonomous nervous function (i.e., heart rate variability during an orthostatic test) as well as questionnaire-assessed quality of life (EORTC QLQ-C30) were evaluated before and after the intervention.No adverse events were reported throughout the training intervention and a 3 months follow-up. While the patient attended all sessions, adherence to total training time was only 51% (102 of 200 minutes; mean training time per session 12:44 min:sec). VO2peak and Wmax increased by 13% (from 23.0 to 26.1 mL min kg) and 21% (from 83 to 100 W), respectively. Heart rate variability represented by the root mean squares of successive differences both in supine and upright positions were increased after the training by 143 and 100%, respectively. The EORTC QLQ-C30 score for physical functioning (7.5%) as well as the global health score (10.7%) improved, while social function decreased (17%).
Our results show that a already short period of HIIT with concomitant hyperoxia was safe and feasible for a patient undergoing chemotherapy for colon cancer. Furthermore, the low overall training adherence of only 51% and an overall low training time per session (∼13 minutes) was sufficient to induce clinically meaningful improvements in physical functioning. However, this case also underlines that intensity and/or length of the HIIT-bouts might need further adjustments to increase training compliance.
我们进行了一项案例研究，以检验在一名接受化疗的结肠癌患者中，增加吸入氧含量的高强度间歇训练（HIIT）的可行性和安全性。第二个目的是研究这种训练方案对身体机能的影响。
一名女性患者（51岁；体重49.1千克；身高1.65米；肿瘤分期：pT3、pN2a（5/29）、pM1a（肝转移）、L0、V0、R0）进行了8次HIIT训练（每次90%最大摄氧量强度下进行5×3分钟，中间间隔2分钟45%最大摄氧量强度），吸入氧分数增加至30%。在干预前后评估了患者安全性、训练依从性、心肺适能（递增式蹬车测试中的峰值摄氧量和最大功率输出）、自主神经功能（即直立试验中的心率变异性）以及问卷评估的生活质量（欧洲癌症研究与治疗组织QLQ-C30量表）。在整个训练干预及3个月随访期间均未报告不良事件。虽然患者参加了所有训练课程，但总训练时间的依从性仅为51%（200分钟中的102分钟；每次训练平均时间12分44秒）。峰值摄氧量和最大摄氧量分别增加了13%（从23.0增至26.1毫升·分钟·千克）和21%（从83瓦增至100瓦）。训练后，仰卧位和直立位连续差值均方根所代表的心率变异性分别增加了143%和100%。欧洲癌症研究与治疗组织QLQ-C30量表的身体机能评分（7.5%）以及总体健康评分（10.7%）有所改善，而社会功能评分下降（17%）。
我们的结果表明，对于一名接受结肠癌化疗的患者，即使是短时间的HIIT联合高氧治疗也是安全可行的。此外，总体训练依从性仅51%且每次训练总时间较短（约13分钟），就足以在身体机能方面带来具有临床意义的改善。然而，该案例也强调，HIIT训练的强度和/或时长可能需要进一步调整，以提高训练依从性。
