Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore-560012, India.
Dalton Trans. 2018 Jun 25;47(25):8466-8475. doi: 10.1039/c8dt00962g.
Coordination-driven self-assembly of organometallic η6-arene ruthenium(ii) supramolecular architectures (MA1-MA4) was carried out by employing dinuclear ruthenium acceptors Ru2(μ-η4-C2O4)(CH3OH)2(η6-p-cymene)22 (Rua), Ru2(μ-η4-C6H2O4)(CH3OH)2(η6-p-cymene)22 (Rub), Ru2(dhnq)(H2O)2(η6-p-cymene)22 (Ruc) and Ru2(dhtq)(H2O)2(η6-p-cymene)22 (Rud) separately with a new tetratopic donor (TD) in methanol at room temperature [TD = N,N,N',N'-tetra(pyridin-4-yl)-[1,1'-biphenyl]-4,4'-diamine]. All the coordination architectures were characterized by using spectroscopic techniques. The potency of these self-assembled architectures against human cervical cancer HeLa and human lung adenocarcinoma A549 cell lines is explored in vitro using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), annexin V-FITC/PI and 2',7'-dichlorofluorescein-diacetate assays.
采用双核钌受体Ru2(μ-η4-C2O4)(CH3OH)2(η6-p-cymene)22 (Rua)、Ru2(μ-η4-C6H2O4)(CH3OH)2(η6-p-cymene)22 (Rub)、Ru2(dhnq)(H2O)2(η6-p-cymene)22 (Ruc) 和 Ru2(dhtq)(H2O)2(η6-p-cymene)22 (Rud)，通过四齿供体（TD）在甲醇中室温下进行配位驱动的有机金属η6-芳基钌(ii)超分子结构（MA1-MA4）的自组装。所有配位结构均通过光谱技术进行了表征。使用 MTT（3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐）、Annexin V-FITC/PI 和 2',7'-二氯荧光素二乙酸酯测定法在体外探索了这些自组装结构对人宫颈癌 HeLa 和人肺腺癌细胞 A549 系的效力。
