Ajibola Adeyemo Aderonke, Shettar Abhijith, Bhat Imtiyaz Ahmad, Kondaiah Paturu, Mukherjee Partha Sarathi
Department of Inorganic and Physical Chemistry and †Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science , Bangalore 560012, India.
Inorg Chem. 2017 Jan 3;56(1):608-617. doi: 10.1021/acs.inorgchem.6b02488. Epub 2016 Dec 20.
Four new octanuclear Ru(II) cages (OC-1-OC-4) were synthesized from dinuclear p-cymene ruthenium(II) acceptors Ru(μ-η-CO)(CHOH)(η-p-cymene) (A), Ru(μ-η-CHO)(CHOH)(η-p-cymene) (A), Ru(dhnq)(HO)(η-p-cymene) (A), and Ru(dhtq)(HO)(η-p-cymene) (A) separately with a tetradentate pyridyl ligand (L) in methanol using coordination-driven self-assembly [L= N,N,N',N'-tetra(pyridin-4-yl)benzene-1,4-diamine]. The octanuclear cages are fully characterized by various spectroscopic techniques including single-crystal X-ray diffraction analysis of OC-4. The self-assembled cages show strong in vitro anticancer activity against human lung adenocarcinoma A549 and human cervical cancer HeLa cell lines as observed from the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Of all the octanuclear cages, OC-3 exhibits remarkable anticancer activity against both cancer cell lines and is more active than that reported for cisplatin. The excellent anticancer activity of OC-3 and OC-4 highlights the importance of the synergistic effects of the spacer component of the dinuclear p-cymene Ru(II) acceptor clips.
通过配位驱动自组装，分别使用四齿吡啶配体（L）[L = N,N,N',N'-四（吡啶-4-基）苯-1,4-二胺]，由双核对异丙基苯钌（II）受体Ru(μ-η-CO)(CHOH)(η-p-cymene)（A）、Ru(μ-η-CHO)(CHOH)(η-p-cymene)（A）、Ru(dhnq)(HO)(η-p-cymene)（A）和Ru(dhtq)(HO)(η-p-cymene)（A）在甲醇中合成了四个新的八核Ru(II)笼（OC-1 - OC-4）。通过包括OC-4的单晶X射线衍射分析在内的各种光谱技术对八核笼进行了全面表征。从3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四氮唑溴盐试验观察到，自组装笼对人肺腺癌A549和人宫颈癌HeLa细胞系显示出很强的体外抗癌活性。在所有八核笼中，OC-3对两种癌细胞系均表现出显著的抗癌活性，且比顺铂的活性更高。OC-3和OC-4优异的抗癌活性突出了双核对异丙基苯Ru(II)受体夹的间隔组分协同效应的重要性。
