Yamamoto M, Hayashi Y, Tang L L, Mori R
Antiviral Res. 1985 Apr;5(2):83-91. doi: 10.1016/0166-3542(85)90034-8.
Antiviral effects of acyclovir (ACV) and antibody were studied in athymic nude mice inoculated intracutaneously in the midflank with herpes simplex virus type 1. Three hours after virus inoculation, treatment was initiated. In ACV-treated mice, the development of skin lesions was inhibited and the mean survival time was prolonged as compared with controls. Treatment with ACV markedly reduced the viral titers both at the inoculation site and in the neural tissues (dorsal root ganglia, spinal cord and brain). Transfer of antibody was also effective in controlling infection as described previously. The use of ACV plus antibody was more effective than the use of ACV alone and in 5 of 17 mice the disease was completely inhibited. Furthermore, in the mice that survived, latent infections in the ganglia were also prevented. These results indicate that treatment with ACV plus antibody is highly effective against herpes simplex virus infection in the immunocompromised host.
在将1型单纯疱疹病毒经皮接种于无胸腺裸鼠胁腹中部的实验中，研究了阿昔洛韦（ACV）和抗体的抗病毒作用。病毒接种3小时后开始治疗。与对照组相比，接受ACV治疗的小鼠皮肤损伤的发展受到抑制，平均存活时间延长。ACV治疗显著降低了接种部位和神经组织（背根神经节、脊髓和脑）中的病毒滴度。如先前所述，抗体转移在控制感染方面也有效。使用ACV加抗体比单独使用ACV更有效，17只小鼠中有5只疾病被完全抑制。此外，在存活的小鼠中，神经节中的潜伏感染也得到了预防。这些结果表明，ACV加抗体治疗对免疫受损宿主的单纯疱疹病毒感染非常有效。
