Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, China.
Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China.
EBioMedicine. 2018 Jun;32:164-171. doi: 10.1016/j.ebiom.2018.05.033. Epub 2018 Jun 12.
Left ventricular mass index (LVMI) provides a metric for cardiovascular disease risk. We aimed to assess the association of adiponectin-related genetic variants resulting from GWAS in East Asians (loci in/near CDH13, ADIPOQ, WDR11FGF, CMIP and PEPD) with LVMI, and to examine whether sleep duration modified these genetic associations in youth. The 559 subjects aged 15-28 years were recruited from the Beijing Child and Adolescent Metabolic Syndrome study. Among the six loci, CDH13 rs4783244 was significantly correlated with adiponectin levels (p = 8.07 × 10). The adiponectin-rising allele in rs4783244 locus was significantly associated with decreased LVMI (p = 6.99 × 10) after adjusting for classical cardiovascular risk factors, and further for adiponectin levels, while no significant association was found between the other loci and LVMI. Moreover, we observed a significant interaction effect between rs4783244 and sleep duration (p = .005) for LVMI; the genetic association was more evident in long sleep duration while lost in short sleep duration. Similar interaction was found in the subgroup analysis using longitudinal data (p = .025 for interaction). In this young Chinese population, CDH13 rs4783244 represents a key locus for cardiac structure, and confers stronger cardio-protection in longer sleep duration when contrasted with short sleep duration.
左心室质量指数 (LVMI) 提供了心血管疾病风险的衡量标准。我们旨在评估东亚人群 GWAS 中与脂联素相关的遗传变异（位于/附近 CDH13、ADIPOQ、WDR11FGF、CMIP 和 PEPD 的基因座）与 LVMI 的关联，并研究睡眠时长是否会改变这些遗传关联在年轻人中的作用。559 名 15-28 岁的受试者来自北京儿童和青少年代谢综合征研究。在这六个基因座中，CDH13 rs4783244 与脂联素水平显著相关（p=8.07×10）。rs4783244 基因座中的脂联素升高等位基因与 LVMI 降低显著相关（p=6.99×10），在调整了经典心血管危险因素和脂联素水平后仍然如此，而其他基因座与 LVMI 之间没有显著关联。此外，我们观察到 rs4783244 与睡眠时长之间存在显著的交互作用（p=0.005）；在长睡眠时长时，遗传关联更为明显，而在短睡眠时长时则失去了关联。使用纵向数据的亚组分析也发现了类似的交互作用（交互作用的 p 值为 0.025）。在这个年轻的中国人群中，CDH13 rs4783244 是心脏结构的关键基因座，与短睡眠时长相比，长睡眠时长时具有更强的心脏保护作用。
