Drug Ther Bull. 2018 Jun;56(6):69-72. doi: 10.1136/dtb.2018.6.0636.
Paracetamol, on its own or in combination with other analgesics, is widely used to treat pain associated with acute and chronic conditions. It is considered safe enough to have a general sales licence (GSL) for use by "adults, elderly and children over 16 years" and has few listed cautions or contraindications.1,2 However, recently the effectiveness and safety of paracetamol for some conditions have been challenged, 3,4 and there are published case reports of liver failure associated with therapeutic doses.5-9 Here, we review the use of paracetamol, its pharmacokinetics, the mechanisms by which it can cause liver damage and consider whether frail older people are at greater risk of adverse effects. We also discuss if dose reduction should be considered in some circumstances.
对乙酰氨基酚单独使用或与其他镇痛药联合使用时，被广泛用于治疗与急慢性病症相关的疼痛。它被认为足够安全，拥有“成人、老年人及16岁以上儿童”使用的一般销售许可（GSL），且列出的注意事项或禁忌较少。然而，最近对乙酰氨基酚在某些病症中的有效性和安全性受到了质疑，并且有已发表的关于治疗剂量导致肝衰竭的病例报告。在此，我们综述对乙酰氨基酚的使用、其药代动力学、它可导致肝损伤的机制，并考虑体弱的老年人是否面临更高的不良反应风险。我们还讨论了在某些情况下是否应考虑减少剂量。
