Michalczuk Marta, Urban Beata, Porowski Tadeusz, Wasilewska Anna, Bakunowicz-Łazarczyk Alina
Department of Paediatric Ophthalmology and Strabismus, Medical University of Białystok, ul. Waszyngtona 17, 15-274, Białystok, Poland.
Department of Pediatrics and Nephrology, Medical University of Białystok, ul. Waszyngtona 17, 15-274, Białystok, Poland.
Metabolomics. 2018;14(6):82. doi: 10.1007/s11306-018-1377-1. Epub 2018 Jun 5.
Citrate is an old metabolite which is best known for the role in the Krebs cycle. Citrate is widely used in many branches of medicine. In ophthalmology citrate is considered as a therapeutic agent and an useful diagnostic tool-biomarker.
To summarize the published literature on citrate usage in the leading causes of blindness and highlight the new possibilities for this old metabolite.
We conducted a systematic search of the scientific literature about citrate usage in ophthalmology up to January 2018. The reference lists of identified articles were searched for providing in-depth information.
This systematic review included 30 articles. The role of citrate in the leading causes of blindness is presented.
Citrate might help inhibit cataract progression, in case of questions confirm glaucoma diagnosis or improve cornea repair treatment as adjuvant agent (therapy of ulcerating cornea after alkali injury, crosslinking procedure). However, the knowledge about possible citrate usage in ophthalmology is not widely known. Promoting recent scientific knowledge about citrate usage in ophthalmology may not only benefit of medical improvement but may also limit economic costs caused by leading causes of blindness. Further studies on citrate usage in ophthalmology should continuously be the field of scientific interest.
柠檬酸盐是一种古老的代谢产物，最为人所知的是其在三羧酸循环中的作用。柠檬酸盐在医学的许多分支中都有广泛应用。在眼科领域，柠檬酸盐被视为一种治疗剂和有用的诊断工具——生物标志物。
总结已发表的关于柠檬酸盐在主要致盲原因中的应用的文献，并突出这种古老代谢产物的新应用可能性。
我们对截至2018年1月的有关柠檬酸盐在眼科应用的科学文献进行了系统检索。对已识别文章的参考文献列表进行检索以获取深入信息。
本系统评价纳入了30篇文章。阐述了柠檬酸盐在主要致盲原因中的作用。
柠檬酸盐可能有助于抑制白内障进展，在某些情况下可辅助确诊青光眼或改善角膜修复治疗（碱烧伤后溃疡性角膜的治疗、交联手术）。然而，关于柠檬酸盐在眼科可能的应用的知识并不广为人知。推广近期关于柠檬酸盐在眼科应用的科学知识不仅可能有益于医学进步，还可能限制主要致盲原因所带来的经济成本。眼科领域对柠檬酸盐应用的进一步研究应持续成为科学关注的领域。
