Michalczuk Marta, Tadeusz Porowski, Urban Beata, Anna Wasilewska, Bakunowicz-Łazarczyk Alina
Department of Paediatric Ophthalmology and Strabismus, Medical University of Białystok, Białystok, Poland.
Department of Pediatrics and Nephrology, Medical University of Białystok, Białystok, Poland.
BMJ Paediatr Open. 2017 Jul 3;1(1):e000023. doi: 10.1136/bmjpo-2017-000023. eCollection 2017.
The main aim of the present study was to examine a possible role of plasma and urine citrate levels as glaucoma indicators in school-aged children with glaucoma diagnosis.
34 school-aged children with a glaucoma diagnosis (mean age 15.69±1.86 years) were qualified for the study group and 34 patients with no ophthalmological ailments were qualified for the control group (mean age 16.1±1.98 years). Plasma and urine citrate levels in the study and the control group (Kruskal-Wallis test) were compared.
Plasma citrate levels in the study (16.33±4.51 mg/L) and the control group (19.11±3.66 mg/L) were different; the statistical significance (p=0.0036). Plasma citrate concentrations were significantly lower in the study group in comparison with the control group. There were no statistically important differences between the study group (291.12±259.13 mg/24 hours; 275.82±217.57 mg/g) and the control group (434.88±357.66 mg/24 hours; 329.81±383.27 mg/g) including urine citrate level (p=0.052) and urine citrate to creatine ratio (p=0.4667).
Plasma citrate concentration might be considered as glaucoma biomarker in paediatric population.
本研究的主要目的是探讨血浆和尿液中柠檬酸盐水平作为青光眼诊断指标在学龄期青光眼患儿中的可能作用。
34名被诊断为青光眼的学龄儿童（平均年龄15.69±1.86岁）被纳入研究组，34名无眼科疾病的患者被纳入对照组（平均年龄16.1±1.98岁）。比较研究组和对照组的血浆和尿液柠檬酸盐水平（Kruskal-Wallis检验）。
研究组（16.33±4.51mg/L）和对照组（19.11±3.66mg/L）的血浆柠檬酸盐水平不同；具有统计学意义（p=0.0036）。与对照组相比，研究组的血浆柠檬酸盐浓度显著降低。研究组（291.12±259.13mg/24小时；275.82±217.57mg/g）和对照组（434.88±357.66mg/24小时；329.81±383.27mg/g）之间在尿液柠檬酸盐水平（p=0.052）和尿液柠檬酸盐与肌酸比值（p=0.4667）方面没有统计学上的显著差异。
血浆柠檬酸盐浓度可被视为儿童青光眼的生物标志物。
