离液剂阴离子硫氰酸盐和高氯酸盐对蓖麻毒素进入非洲绿猴肾细胞的影响。
Effect of the chaotropic anions thiocyanate and perchlorate on the entry of ricin into Vero cells.
作者信息
Sandvig K, Olsnes S
出版信息
Biochem J. 1985 Jun 1;228(2):521-3. doi: 10.1042/bj2280521.
Abstract
The effect of different anions on the sensitivity of Vero cells to ricin was investigated. The cells were equally sensitive to ricin when NaCl was replaced by NaBr, NaI, Na2SO4 or with iso-osmotic concentrations of mannitol. In contrast, NaSCN and NaClO4 strongly protected against ricin at pH 7.2, but not at pH 7.6. The possibility that the protective effect is due to the ability of chaotropic anions to decrease the pH close to the membrane is discussed.
摘要
研究了不同阴离子对Vero细胞对蓖麻毒素敏感性的影响。当用NaBr、NaI、Na2SO4或等渗浓度的甘露醇替代NaCl时，细胞对蓖麻毒素的敏感性相同。相比之下，NaSCN和NaClO4在pH 7.2时能强烈保护细胞免受蓖麻毒素的影响，但在pH 7.6时则不能。讨论了这种保护作用可能是由于离液序列高的阴离子降低膜附近pH值的能力。
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