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离液剂阴离子硫氰酸盐和高氯酸盐对蓖麻毒素进入非洲绿猴肾细胞的影响。

Effect of the chaotropic anions thiocyanate and perchlorate on the entry of ricin into Vero cells.

作者信息

Sandvig K, Olsnes S

出版信息

Biochem J. 1985 Jun 1;228(2):521-3. doi: 10.1042/bj2280521.

DOI:10.1042/bj2280521
PMID:2990449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1145012/
Abstract

The effect of different anions on the sensitivity of Vero cells to ricin was investigated. The cells were equally sensitive to ricin when NaCl was replaced by NaBr, NaI, Na2SO4 or with iso-osmotic concentrations of mannitol. In contrast, NaSCN and NaClO4 strongly protected against ricin at pH 7.2, but not at pH 7.6. The possibility that the protective effect is due to the ability of chaotropic anions to decrease the pH close to the membrane is discussed.

摘要

研究了不同阴离子对Vero细胞对蓖麻毒素敏感性的影响。当用NaBr、NaI、Na2SO4或等渗浓度的甘露醇替代NaCl时，细胞对蓖麻毒素的敏感性相同。相比之下，NaSCN和NaClO4在pH 7.2时能强烈保护细胞免受蓖麻毒素的影响，但在pH 7.6时则不能。讨论了这种保护作用可能是由于离液序列高的阴离子降低膜附近pH值的能力。

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本文引用的文献

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J Biol Chem. 1982 Jul 10;257(13):7495-503.
2
Anion requirement and effect of anion transport inhibitors on the response of vero cells to diphtheria toxin and modeccin.阴离子需求以及阴离子转运抑制剂对非洲绿猴肾细胞对白喉毒素和相思子毒素反应的影响。
J Cell Physiol. 1984 Apr;119(1):7-14. doi: 10.1002/jcp.1041190103.
3
Interfacial pH at electrically charged lipid monolayers investigated by the lipoid pH-indicator method.
Biochim Biophys Acta. 1974 Aug 9;356(3):270-5. doi: 10.1016/0005-2736(74)90267-3.
4
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Biochemistry. 1973 Jul 31;12(16):3121-6. doi: 10.1021/bi00740a028.
5
Isolation and properties of abrin: a toxic protein inhibiting protein synthesis. Evidence for different biological functions of its two constituent-peptide chains.相思豆毒素的分离与特性：一种抑制蛋白质合成的毒性蛋白。关于其两条组成肽链不同生物学功能的证据。
Eur J Biochem. 1973 May;35(1):179-85. doi: 10.1111/j.1432-1033.1973.tb02823.x.
6
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Biochem Biophys Res Commun. 1978 Feb 28;80(4):849-57. doi: 10.1016/0006-291x(78)91322-0.
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