Section of Biomedical Genetics, Boston University School of Medicine and The Department of Biostatistics, Boston University School of Public Health , Boston, Massachusetts.
Department of Pharmacology & Experimental Therapeutics and The Whitaker Cardiovascular Institute, Boston University School of Medicine , Boston, Massachusetts.
Physiol Genomics. 2018 Sep 1;50(9):724-725. doi: 10.1152/physiolgenomics.00141.2017. Epub 2018 Jun 15.
Salt sensitivity of blood pressure (BP) increases hypertension risk and associated adverse cardiovascular outcomes. At present, there are no validated rapid tests or diagnostic markers to identify salt sensitivity of BP in clinical practice. Based on our prior animal studies that report a role for brain Gαi proteins in the salt sensitivity of BP and evidence that GNAI2 single nucleotide polymorphisms (SNPs) associate with hypertension risk, we investigated the hypothesis that GNAI2 SNPs associate with salt sensitivity of BP in humans. Our data provide the first evidence that a GNAI2 SNP ( rs10510755 ) positively associates with salt sensitivity of BP in the Genetic Epidemiology of Salt Sensitivity data set (continuous phenotype P = 0.049, case-control phenotype P = 0.039; n = 968), independently of subject sex or age. These observations suggest that genotyping at GNAI2 may be a useful biomarker in identifying individuals at risk for developing salt-sensitive BP and related complications or in identifying salt sensitivity within the hypertensive population.
血压的盐敏感性会增加高血压风险和相关心血管不良结局。目前，临床上尚无经过验证的快速检测或诊断标志物来识别血压的盐敏感性。基于我们之前的动物研究报告了脑 Gαi 蛋白在血压盐敏感性中的作用，以及 GNAI2 单核苷酸多态性（SNP）与高血压风险相关的证据，我们研究了 GNAI2 SNP 与人类血压盐敏感性之间是否存在关联的假设。我们的数据首次提供了证据表明，GNAI2 SNP（rs10510755）与遗传流行病学中盐敏感性数据集中的血压盐敏感性呈正相关（连续表型 P=0.049，病例对照表型 P=0.039；n=968），独立于受试者的性别或年龄。这些观察结果表明，GNAI2 的基因分型可能是一种有用的生物标志物，可用于识别易发生盐敏感性高血压及相关并发症的个体，或用于识别高血压人群中的盐敏感性。
