State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, PR China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, PR China.
Fitoterapia. 2018 Sep;129:126-132. doi: 10.1016/j.fitote.2018.06.005. Epub 2018 Jun 12.
Five new iridal-type triterpenoids, named as spirioiridoconfal A-C (1-3), isobelamcandal (4) and 17-hydroxyl-27-ene-iridal (5), along with one known compound (6) were isolated from the whole plant of Iris confusa. Their structures were determined by extensive spectroscopic analyses. Compounds 3 and 6 showed moderate activity against HBV DNA replication in vitro with the IC value at 84.6 ± 24.9 (SI = 2.1) and 58.6 ± 6.1 (SI = 12.7) μM relatively.
从鸢尾属植物中分离得到了 5 个新的艾里多烷型三萜类化合物，分别命名为螺旋艾里多烷酮 A-C（1-3）、异贝拉坎达（4）和 17-羟基-27-烯-艾里多烷（5），以及一个已知化合物（6）。通过广泛的光谱分析确定了它们的结构。化合物 3 和 6 对 HBV DNA 复制具有中等抑制活性，IC 值分别为 84.6 ± 24.9（SI = 2.1）和 58.6 ± 6.1（SI = 12.7）μM。
