State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China.
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China.
J Hazard Mater. 2018 Sep 5;357:341-347. doi: 10.1016/j.jhazmat.2018.05.058. Epub 2018 May 28.
Contaminants, such as polycyclic aromatic hydrocarbons (PAHs), can be absorbed on the particles of indoor dust, which may pose potential health risks. In this study, indoor dust samples were collected and sieved into 6 size fractions (i.e., <43 μm, 43-63 μm, 63-100 μm, 100-150 μm, 150-200 μm, and 200-2000 μm). Ingestion bioaccessibility of PAHs was measured by physiologically based extraction test. Bioaccessibility in fractions of 200-2000 μm was generally higher than those in other particle sizes. Daily uptake doses based on benzo(a)pyrene toxic equivalency quantity were 1.09-15.0 ng/d/kg, and peaked at fractions of <43 μm, while doses considering bioaccessibility ranged from 0.02 to 0.21 ng/d/kg, and peaked at fractions with relatively larger particle size. Cell toxicity was also investigated by human normal liver cell line viability through exposure to organic extracts of indoor dust fractions with various particle sizes. Our results indicated that it is crucial to consider dust particle size and bioaccessibility during risk assessment.
污染物，如多环芳烃 (PAHs)，可能会被室内灰尘颗粒吸附，从而构成潜在的健康风险。在本研究中，采集了室内灰尘样本并筛分成 6 个粒径分数（即 <43μm、43-63μm、63-100μm、100-150μm、150-200μm 和 200-2000μm）。通过生理基础提取测试来测量 PAHs 的摄入生物可给性。粒径为 200-2000μm 的分数中的生物可给性通常高于其他粒径分数中的生物可给性。基于苯并(a)芘毒性等效数量的每日摄取剂量为 1.09-15.0ng/d/kg，峰值出现在粒径<43μm 的分数中，而考虑生物可给性的剂量范围在 0.02 到 0.21ng/d/kg 之间，峰值出现在粒径相对较大的分数中。还通过暴露于不同粒径的室内灰尘分数的有机提取物来研究人正常肝细胞系活力，以考察细胞毒性。我们的研究结果表明，在风险评估中，考虑灰尘颗粒大小和生物可给性至关重要。
