Department of Nano Bio Research, National NanoFab Center (NNFC), Daejeon, 34141, Republic of Korea.
Department of Nano Bio Research, National NanoFab Center (NNFC), Daejeon, 34141, Republic of Korea; Department of Advanced Materials Science and Engineering, Hanbat National University, Daejeon, 34158, Republic of Korea.
Colloids Surf B Biointerfaces. 2018 Oct 1;170:172-178. doi: 10.1016/j.colsurfb.2018.06.007. Epub 2018 Jun 6.
Antibacterial activity is essential and highly demanded in worldwide to prevent potential bacterial infection. Here in this work, we report a new approch for the fabrication of flexible zinc oxide nanopillar arrays (ZG-NPA) film with an efficient antibacterial activity. A flexible NPA film served as a substrate for the rapid formation of ZnO by using ultrasound-assisted method. The enhancement of antibacterial activity were induced by cellular damages because of nano topological effects and electrostatic interaction between bacteria and ZG-NPA. Owing to the benefits of combination with flexibility, high surface areas from nano-features and excellent antibacterial efficiency (>80%) of ZG-NPA, the film can show great potential for use as novel biomaterials for preventing bacterial infections.
抗菌活性在全球范围内至关重要且需求量极大，可用于预防潜在的细菌感染。在这项工作中，我们报告了一种新方法，可用于制造具有高效抗菌活性的氧化锌纳米柱阵列（ZG-NPA）柔性薄膜。该柔性 NPA 薄膜可作为基底，通过超声辅助法快速形成 ZnO。纳米拓扑效应和细菌与 ZG-NPA 之间的静电相互作用会导致细胞损伤，从而增强抗菌活性。由于与柔韧性相结合的优势、纳米特性带来的高表面积以及 ZG-NPA 出色的抗菌效率（>80%），该薄膜在用作预防细菌感染的新型生物材料方面具有巨大潜力。
