Department of Earth and Planetary Sciences, Weizmann Institute of Science, 7610001, Rehovot, Israel.
Department of Earth and Planetary Sciences, Weizmann Institute of Science, 7610001, Rehovot, Israel.
Chemosphere. 2018 Oct;208:829-837. doi: 10.1016/j.chemosphere.2018.06.015. Epub 2018 Jun 5.
This study reports the transport characteristics of the organometallic anticancer compound oxaliplatin and its derivatives in natural soil-water environments. Although pharmaceuticals and their derivatives have for many years been detected in water resources, and linked to toxicological impacts on ecological systems, their transport in soil and groundwater is not fully understood. Specifically, studies that describe transport of organometallic pharmaceuticals in porous media are rare, and the transport characteristics of platinum complexes have received little attention. Oxaliplatin transport was studied in sand, as a function of two added natural chelators (citrate and humic acid), and in soil, under four continuously monitored, environmentally-relevant redox conditions: oxic, nitrate reducing, iron reducing and methanogenic. In sand, oxaliplatin species retention was about 7%, and affected only mildly by added citrate, and by humic acid under buffered pH. Transport with unbuffered humic acid was affected significantly by pH variations, and exhibited strong retention at pH < 8. In soil, unexpectedly similar breakthrough patterns of oxaliplatin species were found for all redox conditions, exhibiting linear, reversible retention of 79-87%. The strongest retention was observed under iron reducing conditions, whereas the weakest retention was under oxic conditions. Increased cation activity appears to promote weaker sorption. The results indicate that soil composition is the leading factor affecting oxaliplatin species mobility and fate in the soil-water environment, followed by the weaker factors of redox conditions and cation activities.
本研究报告了有机金属抗癌化合物奥沙利铂及其衍生物在自然土壤-水环境中的传输特性。尽管药品及其衍生物多年来一直被检测到在水资源中，并与对生态系统的毒理学影响有关，但它们在土壤和地下水中的传输情况尚未完全了解。具体而言，描述有机金属药品在多孔介质中传输的研究很少，铂配合物的传输特性也很少受到关注。奥沙利铂的传输在沙中进行，作为两个添加的天然螯合剂（柠檬酸盐和腐殖酸）的函数，以及在土壤中，在四种连续监测的、与环境相关的氧化还原条件下进行：有氧、硝酸盐还原、铁还原和产甲烷。在沙中，奥沙利铂的保留率约为 7%，仅受到添加的柠檬酸盐和缓冲 pH 值下的腐殖酸的轻微影响。未缓冲腐殖酸的传输受到 pH 值变化的显著影响，在 pH < 8 时表现出强烈的保留。在土壤中，对于所有氧化还原条件，奥沙利铂的保留模式都非常相似，表现出 79-87%的线性、可逆保留。在铁还原条件下观察到最强的保留，而在有氧条件下保留最弱。阳离子活性的增加似乎促进了较弱的吸附。结果表明，土壤成分是影响奥沙利铂在土壤-水环境中迁移和归宿的主要因素，其次是氧化还原条件和阳离子活性等较弱因素。
