利福喷丁和异烟肼治疗血液透析患者潜伏性结核感染：不良事件发生率高。
Three months of rifapentine and isoniazid for latent tuberculosis infection in hemodialysis patients: High rates of adverse events.
机构信息
Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; School of Medicine, Graduate Institute of Medicine, Sepsis Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
出版信息
J Microbiol Immunol Infect. 2019 Feb;52(1):158-162. doi: 10.1016/j.jmii.2018.05.003. Epub 2018 Jun 2.
The consequences of once-weekly rifapentine plus isoniazid for 3 months (3HP) against latent tuberculosis infections in hemodialysis patients have not been studied before. This is the first study to evaluate the safety and tolerability of 3HP in this population and revealed a completion rate of 65.4%. The therapy was not associated with hepatotoxicity, but with high rates of adverse events (69.2%).
利福喷汀加异烟肼每周 1 次治疗 3 个月（3HP）方案治疗血液透析患者潜伏性结核感染的后果此前尚未研究过。这是第一项评估该人群中 3HP 安全性和耐受性的研究，结果显示完成率为 65.4%。该治疗方案与肝毒性无关，但与较高的不良事件发生率（69.2%）有关。
Zotero 插件