Department of Innovative Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan
Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
Br J Ophthalmol. 2018 Dec;102(12):1615-1620. doi: 10.1136/bjophthalmol-2018-312333. Epub 2018 Jun 15.
The precorneal tear film is maintained by blinking and exhibits different phases in the tear cycle. The tear film serves as the most anterior surface of the eye and plays an important role as a first refractive component of the eye. Alterations in tear film dynamics may cause both vision-related and ocular surface-related symptoms. Although the optical quality associated with the tear film dynamics previously received little attention, objective measurements of optical quality using wavefront sensors have enabled us to quantify optical aberrations induced by the tear film. This has provided an objective method for assessing reduced optical quality in dry eye; thus, visual disturbances were included in the definition of dry eye disease in the 2007 Dry Eye Workshop report. In addition, sequential measurements of wavefront aberrations have provided us with valuable insights into the dynamic optical changes associated with tear film dynamics. This review will focus on the current knowledge of the mechanisms of wavefront variations that are caused by different aspects of tear film dynamics: specifically, quality, quantity and properties of the tear film, demonstrating the respective effects of dry eye, epiphora and instillation of eye drops on the quality of vision.
角膜前泪膜由眨眼维持，并在泪液循环中呈现不同的阶段。泪膜是眼睛的最前表面，作为眼睛的第一个折射成分起着重要作用。泪膜动力学的改变可能导致与视觉相关和眼表面相关的症状。尽管与泪膜动力学相关的光学质量以前受到的关注较少，但使用波前传感器对光学质量进行客观测量使我们能够量化泪膜引起的像差。这为评估干眼症中的光学质量下降提供了一种客观方法；因此，视觉障碍被纳入 2007 年干眼症研讨会报告中干眼症疾病的定义。此外，波前像差的连续测量为我们提供了有关与泪膜动力学相关的动态光学变化的有价值的见解。这篇综述将重点介绍由泪膜动力学的不同方面引起的波前变化机制的最新知识：具体来说，泪膜的质量、数量和性质，展示了干眼症、溢泪和滴眼剂滴眼对视力质量的各自影响。
