Kaštelan Snježana, Gabrić Ksenija, Mikuličić Maša, Mrazovac Zimak Danijela, Karabatić Mirela, Gverović Antunica Antonela
Department of Ophthalmology, Fundamentals of Medical Skills, School of Medicine, University of Zagreb, Clinical Hospital Dubrava, 10 000 Zagreb, Croatia.
Optomed d.o.o., 10 000 Zagreb, Croatia.
Vision (Basel). 2024 Feb 26;8(1):8. doi: 10.3390/vision8010008.
The prevalence of dry eye disease (DED) is increasing globally, resulting in a variety of eye symptoms characterized by discomfort and visual disturbances. The accurate diagnosis of the disease is often challenging and complex, requiring specialized diagnostic tools. This study aimed to investigate the impact of tear film instability on visual function and to evaluate the value of post-blink blur time (PBBT) as an alternative method for assessing tear film stability.
The study included 62 subjects: 31 with subjective symptoms of DED (Group A) and a control group consisting of 31 healthy participants (Group B). Symptoms were assessed using the standard Schein questionnaire, supplemented with additional questions. PBBT was measured using standard Snellen charts to investigate a potential association between PBBT and tear film dysfunction. Additional clinical assessments included tear film break-up time (TBUT).
Statistically significant differences were observed in the average values of PBBT and TBUT between the examined groups. The average PBBT was 8.95 ± 5.38 s in the group with DED and 14.66 ± 10.50 s in the control group, < 0.001. Group A exhibited an average TBUT of 4.77 ± 2.37 s, while Group B had a TBUT of 7.63 ± 3.25 s, < 0.001. Additionally, a strong positive correlation was identified between PBBT and TBUT values (r = 0.455; < 0.001).
The research confirms that tear film stability has an important role in the refraction of light and the maintenance of optical quality of vision. PBBT could potentially function as an objective and clinically significant screening test for DED.
全球干眼症(DED)的患病率正在上升,导致出现以不适和视觉障碍为特征的多种眼部症状。该疾病的准确诊断通常具有挑战性且复杂,需要专门的诊断工具。本研究旨在调查泪膜不稳定对视觉功能的影响,并评估眨眼后模糊时间(PBBT)作为评估泪膜稳定性的替代方法的价值。
该研究纳入了62名受试者:31名有DED主观症状的患者(A组)和由31名健康参与者组成的对照组(B组)。使用标准的谢恩问卷评估症状,并补充其他问题。使用标准的斯内伦视力表测量PBBT,以研究PBBT与泪膜功能障碍之间的潜在关联。其他临床评估包括泪膜破裂时间(TBUT)。
在被检查组之间,PBBT和TBUT的平均值存在统计学上的显著差异。DED组的平均PBBT为8.95±5.38秒,对照组为14.66±10.50秒,<0.001。A组的平均TBUT为4.77±2.37秒,而B组的TBUT为7.63±3.25秒,<0.001。此外,PBBT和TBUT值之间存在强正相关(r = 0.455;<0.001)。
该研究证实泪膜稳定性在光的折射和视觉光学质量的维持中起重要作用。PBBT可能作为DED的一种客观且具有临床意义的筛查测试。