Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.
HLA Foundation Laboratory, Kyoto, Japan.
Bone Marrow Transplant. 2019 Feb;54(2):300-303. doi: 10.1038/s41409-018-0263-9. Epub 2018 Jun 15.
A human leukocyte antigen (HLA)-matched unrelated donor is the primary alternative donor for allogeneic hematopoietic cell transplantation in Japan. In considering an optimal donor registry size, the availability of HLA-matched donors is important. In this study, the probability of finding an HLA-A, -B, -C, and -DRB1 allele-matched donor was estimated using two different methods based on the haplotype frequencies in the Japanese population: an actual measurement method (AMM) and a formula method (FM). According to AMM, the probabilities of finding an HLA-matched donor were 40.5% in 100,000 donors, 54.4% in 300,000, 60.0% in 500,000, and 63.4% in 700,000. On the other hand, according to FM, the probabilities were 47.8% in 100,000 donors, 59.9% in 300,000, 65.3% in 500,000, and 68.8% in 700,000. The probabilities increased by 8.6 or 7.7%, 3.2 or 3.1%, 2.1 or 1.9%, and 1.6 or 1.3% in AMM or FM, respectively, as the registry size increased by 100,000. The rate of increase in the probability of finding an HLA-matched donor will become smaller as the registry size increases due to the diversity of haplotypes. Therefore, it is important to set a target donor registry size for efficient donor recruitment by considering the haplotype frequencies in the population.
人类白细胞抗原 (HLA) 匹配的无关供者是日本异基因造血细胞移植的主要替代供者。在考虑最佳供者登记册规模时，HLA 匹配供者的可用性很重要。在这项研究中，使用基于日本人群中单体型频率的两种不同方法（实际测量法 [AMM] 和公式法 [FM]）来估计找到 HLA-A、-B、-C 和 -DRB1 等位基因匹配供者的概率。根据 AMM，在 10 万名供者中找到 HLA 匹配供者的概率为 40.5%，在 30 万名供者中为 54.4%，在 50 万名供者中为 60.0%，在 70 万名供者中为 63.4%。另一方面，根据 FM，在 10 万名供者中找到 HLA 匹配供者的概率为 47.8%，在 30 万名供者中为 59.9%，在 50 万名供者中为 65.3%，在 70 万名供者中为 68.8%。AMM 或 FM 中，登记册规模每增加 10 万，概率分别增加 8.6 或 7.7%、3.2 或 3.1%、2.1 或 1.9%和 1.6 或 1.3%。由于单体型的多样性，随着登记册规模的增加，找到 HLA 匹配供者的概率增加率会变小。因此，考虑人群中的单体型频率，设定一个有效的供者招募目标登记册规模非常重要。
