Department of Pediatrics, Chang Gung Memorial Hospital - Kaohsiung Medical Center, Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taiwan.
Genomics and Proteomics Core Laboratory, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Cancer Lett. 2018 Oct 1;433:99-106. doi: 10.1016/j.canlet.2018.06.014. Epub 2018 Jun 13.
Neonates have an immature immune system; therefore, their immune activities are different from the activities of adult immune systems. Such differences between neonates and adults are reflected by cell population constitutions, immune responses, cytokine production, and the expression of cellular/humoral molecules, which contribute to the specific neonatal microbial susceptibility and atopic properties. MicroRNAs (miRNAs) have been discovered to modulate many aspects of immune responses. Herein, we summarize the distinct manifestations of the neonatal immune system, including cellular and non-cellular components. We also review the current findings on the modulatory effects of miRNAs on the neonatal immune system. These findings suggest that miRNAs have the potential to be useful therapeutic targets for certain infection or inflammatory conditions by modulating the neonatal immune system. In the future, we need a more comprehensive understanding in regard to miRNAs and how they modulate specific immune cells in neonates.
新生儿的免疫系统尚未成熟；因此，他们的免疫活动与成人免疫系统的活动不同。新生儿和成人之间的这些差异反映在细胞群体组成、免疫反应、细胞因子产生和细胞/体液分子的表达上，这有助于新生儿对特定微生物的易感性和特应性特征。现已发现 microRNAs（miRNAs）可调节免疫反应的许多方面。在此，我们总结了新生儿免疫系统的不同表现，包括细胞和非细胞成分。我们还回顾了 miRNA 对新生儿免疫系统的调节作用的最新发现。这些发现表明，miRNAs 有可能通过调节新生儿的免疫系统，成为治疗某些感染或炎症疾病的有用治疗靶点。未来，我们需要更全面地了解 miRNA 以及它们如何调节新生儿特定免疫细胞。
