Department of Pathology, School of Basic Medicine, Guangdong Medical University, Dongguan 523808, Guangdong Province, China.
Department of Pathology, School of Basic Medicine, Guangdong Medical University, Dongguan 523808, Guangdong Province, China.
Gene. 2018 Oct 5;673:130-133. doi: 10.1016/j.gene.2018.06.034. Epub 2018 Jun 22.
Abnormal regulation of gene expression is essential for tumorigenesis. Several studies indicate that regulation of oncogene expression and neoplastic transformation are controlled by subunits of eukaryotic translation initiation factors (eIFs). Eukaryotic translation initiation factor 3 (eIF3) is the largest (800 kDa) and the most complex mammalian initiation factor. It is composed of 13 non-identical polypeptides designated as eIF3a-m and plays a pivotal role in protein synthesis that bridges the 43S pre-initiation complex and eIF4F-bound mRNA. However, the functional roles of individual subunits are not yet very clear. This review presents on several of aberrant expressed eIF3 subunits which are detected in various human cancers and the associated mechanisms have been acknowledged or are still not sure. Finally, identifying novel targets and biomarkers for caner is of great importance in early diagnosis and treatment of cancer. eIF3 may be a novel target molecule in drug development for cancer treatment and prevention.
基因表达的异常调控对于肿瘤的发生至关重要。有几项研究表明，癌基因表达的调控和肿瘤的转化是由真核翻译起始因子（eIFs）的亚基控制的。真核翻译起始因子 3（eIF3）是最大的（800kDa）和最复杂的哺乳动物起始因子。它由 13 个非同源多肽组成，命名为 eIF3a-m，在蛋白质合成中起着至关重要的作用，连接 43S 起始前复合物和 eIF4F 结合的 mRNA。然而，各个亚基的功能作用尚不清楚。本文综述了几种在各种人类癌症中检测到的异常表达的 eIF3 亚基及其相关机制已被确认或仍不确定。最后，鉴定癌症的新靶点和生物标志物对于癌症的早期诊断和治疗具有重要意义。eIF3 可能成为癌症治疗和预防药物开发的新靶点分子。
