Environment Agency Austria, Vienna, Austria; Department of Nutritional Sciences, University of Vienna, Vienna, Austria.
Environment Agency Austria, Vienna, Austria.
Int J Hyg Environ Health. 2018 Jul;221(6):985-989. doi: 10.1016/j.ijheh.2018.06.001. Epub 2018 Jun 13.
Reference values (RV) are statistically derived values comprising the rounded 95th percentiles within the 95% confidence interval and indicate the upper margin of background exposure to chemical substances in a population at a given time period. Based on representative national human biomonitoring data on several urinary phthalate metabolites in children, adolescents and adults from 2010 to 2011, RV were derived for the Austrian population based on a IUPAC guideline and the recommendation of the German Human Biomonitoring Commission. The RV (rounded values) for phthalate metabolites in children and adolescents aged 6-15 years are 110 μg/l (confidence interval of 95th population percentile: 83.7-163) for mono-ethyl phthalate (MEP), 45 μg/l (40.9-60.6) for mono-n-butyl phthalate (MnBP), 130 μg/l (126-161) for mono-isobutyl phthalate (MiBP), 25 μg/l (17.8-33.6) for mono-benzyl phthalate (MBzP), 100 μg/l (94.0-126) for the sum of the di(2-ethylhexyl) phthalate (DEHP) metabolites including mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP), mono(2-ethyl-5-oxohexyl) phthalate (5oxo-MEHP) and mono(2-ethyl-5-carboxypentyl) phthalate (5cx-MEPP), and 1.5 μg/l (0.64-1.6) for mono-cyclohexyl phthalate (MCHP). In adults aged 18-81 years, RV are 440 μg/l (353-636) for MEP, 40 μg/l (33.1-52.1) for MnBP, 110 μg/l (87.3-118) for MiBP, 10 μg/l (7.2-11.8) for MBzP, 50 μg/l (44.6-68.3) for the sum of MEHP, 5OH-MEHP, 5oxo-MEHP and 5cx-MEPP, and 1.5 μg/l (0.95-1.8) for MCHP. For almost all investigated metabolites, children and adolescents exhibit higher RV than adults, with the exceptions being MEP and MCHP. Compared to available RV for Germany and Canada, Austrian values are lower for all investigated population groups.
参考值（RV）是通过统计学得出的数值，包括在 95%置信区间内的第 95 个百分位数的整数倍，表明在特定时间段内人群中对化学物质的背景暴露上限。基于 2010 年至 2011 年儿童、青少年和成年人尿液中几种邻苯二甲酸酯代谢物的具有代表性的全国人体生物监测数据，根据 IUPAC 指南和德国人体生物监测委员会的建议，为奥地利人口推导出了邻苯二甲酸酯代谢物的 RV。6-15 岁儿童和青少年的邻苯二甲酸酯代谢物 RV（四舍五入值）为：单乙基邻苯二甲酸酯（MEP）为 110μg/l（95 人口百分位的置信区间：83.7-163），单正丁基邻苯二甲酸酯（MnBP）为 45μg/l（40.9-60.6），单异丁基邻苯二甲酸酯（MiBP）为 130μg/l（126-161），单苄基邻苯二甲酸酯（MBzP）为 25μg/l（17.8-33.6），邻苯二甲酸二（2-乙基己基）酯（DEHP）代谢物之和，包括单（2-乙基己基）邻苯二甲酸酯（MEHP）、单（2-乙基-5-羟基己基）邻苯二甲酸酯（5OH-MEHP）、单（2-乙基-5-氧代己基）邻苯二甲酸酯（5oxo-MEHP）和单（2-乙基-5-羧基戊基）邻苯二甲酸酯（5cx-MEPP）为 100μg/l（94.0-126），单环己基邻苯二甲酸酯（MCHP）为 1.5μg/l（0.64-1.6）。在 18-81 岁的成年人中，RV 为：MEP 为 440μg/l（353-636），MnBP 为 40μg/l（33.1-52.1），MiBP 为 110μg/l（87.3-118），MBzP 为 10μg/l（7.2-11.8），MEHP、5OH-MEHP、5oxo-MEHP 和 5cx-MEPP 的总和为 50μg/l（44.6-68.3），MCHP 为 1.5μg/l（0.95-1.8）。对于几乎所有被调查的代谢物，儿童和青少年的 RV 都高于成年人，MEP 和 MCHP 除外。与德国和加拿大的可用 RV 相比，奥地利的所有被调查人群的数值都较低。
