γ-氨基丁酸能网络与星形胶质细胞网络之间的动态相互作用。

Dynamic interactions between GABAergic and astrocytic networks.

作者信息

Lia Annamaria, Zonta Micaela, Requie Linda Maria, Carmignoto Giorgio

机构信息

University of Padua, Department of Biomedical Sciences, Padua, Italy; CNR, Neuroscience Institute, Padua, Italy.

出版信息

Neurosci Lett. 2019 Jan 10;689:14-20. doi: 10.1016/j.neulet.2018.06.026. Epub 2018 Jun 15.

DOI:10.1016/j.neulet.2018.06.026

PMID:29908949

Abstract

Brain network activity derives from the concerted action of different cell populations. Together with interneurons, astrocytes play fundamental roles in shaping the inhibition in brain circuitries and modulating neuronal transmission. In this review, we summarize past and recent findings that reveal in neural networks the importance of the interaction between GABAergic signaling and astrocytes and discuss its physiological and pathological relevance.

摘要

脑网络活动源于不同细胞群体的协同作用。与中间神经元一起，星形胶质细胞在塑造脑回路中的抑制作用和调节神经元传递方面发挥着重要作用。在这篇综述中，我们总结了过去和最近的研究发现，这些发现揭示了在神经网络中GABA能信号与星形胶质细胞之间相互作用的重要性，并讨论了其生理和病理相关性。