Shi Hongfei, Leng Chaoliang, Xu Qian, Shi Hongling, Sun Shiyu, Kan Yunchao, Yao Lunguang
Henan Provincial Engineering Laboratory of Insects Bio-reactor, China-UK-NYNU-RRes Joint Libratory of Insect Biology, Nanyang Normal University, Nanyang, People's Republic of China.
Liaoning Center for Animal Disease Control and Prevention, Shenyang, People's Republic of China.
Virus Genes. 2018 Aug;54(4):603-607. doi: 10.1007/s11262-018-1579-7. Epub 2018 Jun 16.
Natural Pestivirus H infections in cattle have been reported worldwide; however, only a few cases of Pestivirus H have been described in non-bovine ruminants such as goats. A new Pestivirus H HN1507 strain was isolated from an infected goat in 2015 and the genome sequence was determined. The full-length genome sequence was 12,556 nucleotides. Phylogenetic analysis, based on the complete genome and Npro fragments, revealed that the isolate belonged to Pestivirus H and was closely related to strains from Italy. Two unique amino acid substitutions were found in the C-terminal of the E2 protein. To the best of our knowledge, this is first report determining the complete genome of a Pestivirus H strain from goat.
牛自然感染瘟病毒H的情况在全球均有报道；然而，在山羊等非牛反刍动物中，仅描述了少数瘟病毒H病例。2015年从一只感染山羊中分离出一种新的瘟病毒H HN1507毒株，并测定了其基因组序列。全长基因组序列为12556个核苷酸。基于完整基因组和Npro片段的系统发育分析表明，该分离株属于瘟病毒H，且与来自意大利的毒株密切相关。在E2蛋白的C末端发现了两个独特的氨基酸替换。据我们所知，这是首次报道测定山羊瘟病毒H毒株的完整基因组。
