Ma Yuhang, Li Shumei, Wei Xiaohui, Huang Jingjing, Lai Mengyu, Wang Nian, Huang Qianfang, Zhao Li, Peng Yongde, Wang Yufan
a Department of Endocrinology and Metabolism , Shanghai General Hospital, Shanghai Jiao Tong University , Shanghai , China.
b Shanghai First School of Clinical Medicine , Nanjing Medical University , Shanghai , China.
Gynecol Endocrinol. 2018 Dec;34(12):1064-1067. doi: 10.1080/09513590.2018.1482869. Epub 2018 Jun 17.
Humanin (MT-RNR2) is an endogenous polypeptide that is involved in many diseases, including T2DM. Gestational diabetes mellitus (GDM) is defined as hyperglycemia during pregnancy. The aim of this study was to evaluate serum humanin levels in women with or without GDM and to elucidate possible correlations with anthropometric parameters, metabolic parameters and the incidence of GDM. Eighty-four women with GDM and 73 control women were enrolled in this study. The clinical and biochemical parameters of all subjects were determined. Serum humanin levels were measured by an ELISA. Serum humanin levels were significantly lower in women with GDM than in control women. Moreover, humanin levels were significantly negatively correlated with the presence of GDM, body weight, BMI at 24 weeks of gestation, TG, FPG, 1 hPG, 2 hPG, FINS, and HOMA-IR. In contrast, humanin levels were significantly positively correlated with FT3 and FT4. A binary logistic analysis showed that humanin levels were associated with the incidence of GDM. Additional follow-up studies are needed to highlight whether and how decreased humanin levels play an important role in GDM.
人胰岛素（MT-RNR2）是一种内源性多肽，与包括2型糖尿病（T2DM）在内的多种疾病相关。妊娠期糖尿病（GDM）被定义为孕期高血糖。本研究的目的是评估患有或未患有GDM的女性血清人胰岛素水平，并阐明其与人体测量参数、代谢参数及GDM发病率之间可能存在的相关性。本研究纳入了84例患有GDM的女性和73例对照女性。测定了所有受试者的临床和生化参数。采用酶联免疫吸附测定法（ELISA）检测血清人胰岛素水平。患有GDM的女性血清人胰岛素水平显著低于对照女性。此外，人胰岛素水平与GDM的存在、体重、妊娠24周时的体重指数（BMI）、甘油三酯（TG）、空腹血糖（FPG）、1小时血糖（1 hPG）、2小时血糖（2 hPG）、空腹胰岛素（FINS）及稳态模型评估的胰岛素抵抗指数（HOMA-IR）显著负相关。相反，人胰岛素水平与游离三碘甲状腺原氨酸（FT3）和游离甲状腺素（FT4）显著正相关。二元逻辑分析表明，人胰岛素水平与GDM的发病率相关。需要进一步的随访研究来突出人胰岛素水平降低是否以及如何在GDM中发挥重要作用。
