Ruiz David, Santibañez Miguel, Lavín Bernardo Alio, Berja Ana, Montalban Coral, Vazquez Luis Alberto
Department of Endocrinology, Marqués de Valdecilla University Hospital, Avda Valdecilla, 39008 Santander, Spain.
Nursing Department, University of Cantabria-IDIVAL, Avda Valdecilla, 39008 Santander, Spain.
J Clin Med. 2022 May 26;11(11):3003. doi: 10.3390/jcm11113003.
Our purpose is to study the evolution of mitochondrially derived peptides (MDPs) and their relationship with changes in insulin sensitivity from the early stages of pregnancy in a cohort of pregnant women with and without gestational diabetes (GDM). MDPs (humanin and MOTSc) were assessed in the first and second trimesters of gestation in 28 pregnant women with gestational diabetes mellitus (GDM) and a subgroup of 45 pregnant women without GDM matched by BMI, age, previous gestations, and time of sampling. Insulin resistance (IR) was defined as a HOMA-IR index ≥70th percentile. We observed a significant reduction in both humanin and MOTSc levels from the first to the second trimesters of pregnancy. After adjusting for predefined variables, including BMI, statistically nonsignificant associations between lower levels of humanin and the occurrence of a high HOMA-IR index were obtained (adjusted OR = 2.63 and 3.14 for the first and second trimesters, linear -trend 0.260 and 0.175, respectively). Regarding MOTSc, an association was found only for the second trimester: adjusted OR = 7.68 (95% CI 1.49-39.67), linear -trend = 0.012. No significant associations were observed in humanin change with insulin resistance throughout pregnancy, but changes in MOTSc levels were significantly associated with HOMA-IR index: adjusted OR 3.73 (95% CI 1.03-13.50). In conclusion, MOTSc levels, especially a strong decrease from the first to second trimester of gestation, may be involved in increasing insulin resistance during early gestation.
我们的目的是研究一组患有和未患有妊娠期糖尿病（GDM）的孕妇在妊娠早期线粒体衍生肽（MDPs）的演变及其与胰岛素敏感性变化的关系。在28例患有妊娠期糖尿病（GDM）的孕妇以及按BMI、年龄、既往妊娠情况和采样时间匹配的45例未患GDM的孕妇亚组中，于妊娠的第一和第二孕期评估了MDPs（人胰岛素和MOTSc）。胰岛素抵抗（IR）定义为稳态模型评估胰岛素抵抗（HOMA-IR）指数≥第70百分位数。我们观察到从妊娠的第一孕期到第二孕期，人胰岛素和MOTSc水平均显著降低。在对包括BMI在内的预定义变量进行调整后，人胰岛素水平较低与高HOMA-IR指数的发生之间获得了无统计学意义的关联（第一和第二孕期调整后的比值比分别为2.63和3.14，线性趋势分别为0.260和0.175）。关于MOTSc，仅在第二孕期发现了关联：调整后的比值比 = 7.68（95%可信区间1.49 - 39.67），线性趋势 = 0.012。在整个妊娠期间，未观察到人胰岛素变化与胰岛素抵抗之间的显著关联，但MOTSc水平的变化与HOMA-IR指数显著相关：调整后的比值比为3.73（95%可信区间1.03 - 13.50）。总之，MOTSc水平，尤其是从妊娠第一孕期到第二孕期的显著下降，可能与妊娠早期胰岛素抵抗增加有关。
