Siddeek B, Mauduit C, Yzydorczyk C, Benahmed M, Simeoni U
1Woman-Mother-Child-Department,Division of Pediatrics,DOHaD Laboratory,Centre Hospitalier Universitaire Vaudois and University of Lausanne,Lausanne,Switzerland.
2INSERM U1065,Centre Méditerranéen de Médecine Moléculaire (C3M),Team 5,Nice,France.
J Dev Orig Health Dis. 2018 Dec;9(6):615-631. doi: 10.1017/S2040174418000387. Epub 2018 Jun 18.
Epidemiological and experimental observations tend to prove that environment, lifestyle or nutritional challenges influence heart functions together with genetic factors. Furthermore, when occurring during sensitive windows of heart development, these environmental challenges can induce an 'altered programming' of heart development and shape the future heart disease risk. In the etiology of heart diseases driven by environmental challenges, epigenetics has been highlighted as an underlying mechanism, constituting a bridge between environment and heart health. In particular, micro-RNAs which are involved in each step of heart development and functions seem to play a crucial role in the unfavorable programming of heart diseases. This review describes the latest advances in micro-RNA research in heart diseases driven by early exposure to challenges and discusses the use of micro-RNAs as potential targets in the reversal of the pathophysiology.
流行病学和实验观察倾向于证明，环境、生活方式或营养挑战与遗传因素共同影响心脏功能。此外，在心脏发育的敏感窗口期发生这些环境挑战时，会诱导心脏发育的“编程改变”，并塑造未来患心脏病的风险。在由环境挑战引发的心脏病病因中，表观遗传学已被视为一种潜在机制，它构成了环境与心脏健康之间的桥梁。特别是，参与心脏发育和功能各个阶段的微小RNA似乎在心脏病的不良编程中起着关键作用。本综述描述了早期暴露于各种挑战所引发的心脏病中微小RNA研究的最新进展，并讨论了将微小RNA用作逆转病理生理学潜在靶点的应用。
