Thompson Loren P, Al-Hasan Yazan
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, 11-029 Bressler Research Building, 655 W. Baltimore Street, Baltimore, MD 21201, USA.
J Pregnancy. 2012;2012:582748. doi: 10.1155/2012/582748. Epub 2012 Jul 11.
Intrauterine stress induces increased risk of adult disease through fetal programming mechanisms. Oxidative stress can be generated by several conditions, such as, prenatal hypoxia, maternal under- and overnutrition, and excessive glucocorticoid exposure. The role of oxidant molecules as signaling factors in fetal programming via epigenetic mechanisms is discussed. By linking oxidative stress with dysregulation of specific target genes, we may be able to develop therapeutic strategies that protect against organ dysfunction in the programmed offspring.
宫内应激通过胎儿编程机制增加成年疾病的风险。氧化应激可由多种情况产生，如产前缺氧、母体营养不足和营养过剩以及糖皮质激素暴露过多。本文讨论了氧化分子作为信号因子通过表观遗传机制在胎儿编程中的作用。通过将氧化应激与特定靶基因的失调联系起来，我们或许能够制定出针对程序化后代器官功能障碍的治疗策略。
