Itoh T, Ueno H, Kuriyama H
Experientia. 1985 Aug 15;41(8):989-96. doi: 10.1007/BF01952119.
This article was concerned with the role of Ca in triggering the contraction in vascular smooth muscles. Whenever Ca influx is activated, this Ca does not directly activate the contractile proteins, but rather triggers the release of Ca from the SR to activate calmodulin. This release of Ca by Ca is dependent on the amount of Ca stored within the cells. Voltage dependent Ca influx activated by excess concentrations of K, electrical depolarization and Ca spikes is required to produce the contraction through activation of the Ca-induced Ca release mechanism. The elucidation of the contribution of the P-I response for Ca mobilization through activation of receptors under physiological conditions hopefully will lend support to our hypothesis.
本文关注钙在触发血管平滑肌收缩中的作用。每当钙内流被激活时，这种钙并不直接激活收缩蛋白，而是触发肌浆网释放钙以激活钙调蛋白。钙通过钙来释放钙取决于细胞内储存的钙量。由过量的钾浓度、电去极化和钙峰激活的电压依赖性钙内流，通过激活钙诱导的钙释放机制来产生收缩。阐明在生理条件下通过激活受体的P-I反应对钙动员的贡献有望支持我们的假设。
