Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8549, USA; Department of Molecular & Cellular Endocrinology, Diabetes and Metabolism Research Institute, City of Hope/Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA.
Department of Molecular & Cellular Endocrinology, Diabetes and Metabolism Research Institute, City of Hope/Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA.
Cell Metab. 2018 Aug 7;28(2):282-288.e3. doi: 10.1016/j.cmet.2018.05.022. Epub 2018 Jun 14.
Adipose tissue in the mammary gland undergoes dramatic remodeling during reproduction. Adipocytes are replaced by mammary alveolar structures during pregnancy and lactation, then reappear upon weaning. The fate of the original adipocytes during lactation and the developmental origin of the re-appearing adipocyte post involution are unclear. Here, we reveal that adipocytes in the mammary gland de-differentiate into Pdgfrα preadipocyte- and fibroblast-like cells during pregnancy and remain de-differentiated during lactation. Upon weaning, de-differentiated fibroblasts proliferate and re-differentiate into adipocytes. This cycle occurs over multiple pregnancies. These observations reveal the potential of terminally differentiated adipocytes to undergo repeated cycles of de-differentiation and re-differentiation in a physiological setting.
在生殖过程中，乳腺中的脂肪组织会发生显著的重塑。在怀孕和哺乳期，脂肪细胞被乳腺腺泡结构取代，然后在断奶时再次出现。哺乳期原始脂肪细胞的命运和 involution 后重新出现的脂肪细胞的发育来源尚不清楚。在这里，我们揭示了乳腺中的脂肪细胞在怀孕期间去分化为 PDGFRα 前脂肪细胞和成纤维细胞样细胞，并在哺乳期保持去分化状态。断奶后，去分化的成纤维细胞增殖并重新分化为脂肪细胞。这个周期会在多次怀孕中重复发生。这些观察结果揭示了终末分化的脂肪细胞在生理环境下经历反复去分化和再分化的潜力。
