Department of Neurology & Neurotherapeutics, UT Southwestern, Dallas, TX, USA.
Dysautonomia International, East Moriches, NY, USA.
Auton Neurosci. 2018 Dec;215:78-82. doi: 10.1016/j.autneu.2018.04.005. Epub 2018 Apr 26.
There is growing interest in the role of autoimmunity in postural orthostatic tachycardia syndrome (POTS). In recent years, investigators have described an increased rate of co-morbid autoimmune disease, and the presence of several neural receptor autoantibodies and non-specific autoimmune markers in POTS. Case reports on the efficacy of immunotherapy in highly selected POTS patients continue to appear in the literature, while no prospective clinical trials have occurred to date. This article summarizes the current state of knowledge on the role of autoimmunity in POTS, the clinical implications of these findings, and prospects for future research.
自身免疫在直立位心动过速综合征（POTS）中的作用正受到越来越多的关注。近年来，研究人员描述了并发自身免疫性疾病的发生率增加，以及 POTS 患者中存在几种神经受体自身抗体和非特异性自身免疫标志物。关于免疫疗法在高度选择的 POTS 患者中的疗效的病例报告继续出现在文献中，而迄今为止尚无前瞻性临床试验。本文总结了目前关于自身免疫在 POTS 中的作用、这些发现的临床意义以及未来研究前景的知识现状。
