阿利吉仑对射血分数保留的老年心力衰竭患者运动能力的影响：一项随机、安慰剂对照、双盲试验。
The effect of Aliskiren on exercise capacity in older patients with heart failure and preserved ejection fraction: A randomized, placebo-controlled, double-blind trial.
机构信息
Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC.
出版信息
Am Heart J. 2018 Jul;201:164-167. doi: 10.1016/j.ahj.2018.03.019. Epub 2018 Apr 4.
Abstract
In older patients (70 ± 7 years) with chronic well-compensated heart failure with preserved ejection and controlled blood pressure, 6 months treatment with aliskiren (direct renin inhibitor) showed non-significant trends for modest improvements in peak exercise oxygen consumption (14.9 ± 0.2 mL kg min versus 14.4 ± 0.2 mL kg min; P = .10, trend) and ventilatory anaerobic threshold (888 ± 19 mL/min versus 841 ± 18 mL/min; P = .08).
摘要
在慢性代偿性射血分数保留心力衰竭且血压得到控制的老年患者（70 ± 7 岁）中，使用阿利吉仑（直接肾素抑制剂）治疗 6 个月，峰值运动耗氧量（14.9 ± 0.2 mL·kg-1·min-1 与 14.4 ± 0.2 mL·kg-1·min-1；P =.10，趋势）和通气无氧阈（888 ± 19 mL/min 与 841 ± 18 mL/min；P =.08）有适度改善的非显著趋势。
相似文献
1
The effect of Aliskiren on exercise capacity in older patients with heart failure and preserved ejection fraction: A randomized, placebo-controlled, double-blind trial.阿利吉仑对射血分数保留的老年心力衰竭患者运动能力的影响：一项随机、安慰剂对照、双盲试验。
Am Heart J. 2018 Jul;201:164-167. doi: 10.1016/j.ahj.2018.03.019. Epub 2018 Apr 4.
2
Effect of aliskiren on postdischarge mortality and heart failure readmissions among patients hospitalized for heart failure: the ASTRONAUT randomized trial.阿利吉仑对心力衰竭住院患者出院后死亡率和心力衰竭再入院的影响：ASTRONAUT 随机试验。
JAMA. 2013 Mar 20;309(11):1125-35. doi: 10.1001/jama.2013.1954.
3
A randomized double-blind trial of enalapril in older patients with heart failure and preserved ejection fraction: effects on exercise tolerance and arterial distensibility.一项依那普利治疗老年心力衰竭和射血分数保留患者的随机双盲试验：对运动耐量和动脉可扩张性的影响。
Circ Heart Fail. 2010 Jul;3(4):477-85. doi: 10.1161/CIRCHEARTFAILURE.109.898916. Epub 2010 Jun 1.
4
Effect of additive renin inhibition with aliskiren on renal blood flow in patients with Chronic Heart Failure and Renal Dysfunction (Additive Renin Inhibition with Aliskiren on renal blood flow and Neurohormonal Activation in patients with Chronic Heart Failure and Renal Dysfunction).阿利吉仑联合肾素抑制对慢性心力衰竭和肾功能不全患者肾血流的影响（阿利吉仑联合肾素抑制对慢性心力衰竭和肾功能不全患者肾血流及神经激素激活的影响）
Am Heart J. 2015 May;169(5):693-701.e3. doi: 10.1016/j.ahj.2014.12.016. Epub 2015 Jan 7.
5
Rationale and design of the multicentre, randomized, double-blind, placebo-controlled Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT).多中心、随机、双盲、安慰剂对照的阿利克仑急性心力衰竭结局试验（ASTRONAUT）的原理和设计。
Eur J Heart Fail. 2011 Jan;13(1):100-6. doi: 10.1093/eurjhf/hfq209. Epub 2010 Nov 30.
6
Effect of Aldosterone Antagonism on Exercise Tolerance in Heart Failure With Preserved Ejection Fraction.醛固酮拮抗剂对射血分数保留心力衰竭患者运动耐量的影响。
J Am Coll Cardiol. 2016 Oct 25;68(17):1823-1834. doi: 10.1016/j.jacc.2016.07.763.
7
INDIE-HFpEF (Inorganic Nitrite Delivery to Improve Exercise Capacity in Heart Failure With Preserved Ejection Fraction): Rationale and Design.INDIE-HFpEF（无机亚硝酸盐给药改善射血分数保留的心力衰竭患者运动能力）：原理与设计
Circ Heart Fail. 2017 May;10(5). doi: 10.1161/CIRCHEARTFAILURE.117.003862.
8
Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart failuRE (ATMOSPHERE) study.直接肾素抑制联合或替代血管紧张素转换酶抑制治疗慢性收缩性心力衰竭患者：以降低心力衰竭患者结局为目标的阿利克仑试验（ATMOSPHERE）研究的原理和设计。
Eur J Heart Fail. 2011 Jan;13(1):107-14. doi: 10.1093/eurjhf/hfq212.
9
Blood pressure lowering efficacy of renin inhibitors for primary hypertension.肾素抑制剂对原发性高血压的降压疗效。
Cochrane Database Syst Rev. 2008 Oct 8(4):CD007066. doi: 10.1002/14651858.CD007066.pub2.
10
IL-1 Blockade in Patients With Heart Failure With Preserved Ejection Fraction.白细胞介素-1 阻断剂治疗射血分数保留的心力衰竭患者。
Circ Heart Fail. 2018 Aug;11(8):e005036. doi: 10.1161/CIRCHEARTFAILURE.118.005036.
引用本文的文献
1
Angiotensin-Converting Enzyme and Hypertension: A Systemic Analysis of Various ACE Inhibitors, Their Side Effects, and Bioactive Peptides as a Putative Therapy for Hypertension.血管紧张素转化酶与高血压：各类血管紧张素转化酶抑制剂的系统性分析、它们的副作用，以及作为高血压潜在治疗方法的生物活性肽。
J Renin Angiotensin Aldosterone Syst. 2023 Jun 21;2023:7890188. doi: 10.1155/2023/7890188. eCollection 2023.
2
Renin Activity in Heart Failure with Reduced Systolic Function-New Insights.心力衰竭伴收缩功能障碍患者肾素活性的新认识。
Int J Mol Sci. 2019 Jun 28;20(13):3182. doi: 10.3390/ijms20133182.
3
Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway.骨桥蛋白通过线粒体途径促进左心室舒张功能障碍。
J Am Coll Cardiol. 2019 Jun 4;73(21):2705-2718. doi: 10.1016/j.jacc.2019.02.074.
本文引用的文献
1
Aliskiren, Enalapril, or Aliskiren and Enalapril in Heart Failure.阿利吉仑、依那普利或阿利吉仑和依那普利治疗心力衰竭。
N Engl J Med. 2016 Apr 21;374(16):1521-32. doi: 10.1056/NEJMoa1514859. Epub 2016 Apr 4.
2
Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.热量限制或有氧运动训练对射血分数保留的肥胖老年心力衰竭患者峰值耗氧量和生活质量的影响：一项随机临床试验。
JAMA. 2016 Jan 5;315(1):36-46. doi: 10.1001/jama.2015.17346.
3
Effect of aliskiren on postdischarge mortality and heart failure readmissions among patients hospitalized for heart failure: the ASTRONAUT randomized trial.阿利吉仑对心力衰竭住院患者出院后死亡率和心力衰竭再入院的影响：ASTRONAUT 随机试验。
JAMA. 2013 Mar 20;309(11):1125-35. doi: 10.1001/jama.2013.1954.
4
Reliability of peak exercise testing in patients with heart failure with preserved ejection fraction.射血分数保留的心力衰竭患者运动峰值测试的可靠性。
Am J Cardiol. 2012 Dec 15;110(12):1809-13. doi: 10.1016/j.amjcard.2012.08.015. Epub 2012 Sep 13.
5
Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction.直接肾素抑制剂阿利吉仑对伴收缩功能障碍的心肌梗死后左心室重构的影响。
Eur Heart J. 2011 May;32(10):1227-34. doi: 10.1093/eurheartj/ehq522. Epub 2011 Feb 10.
6
Renal protective effects of aliskiren beyond its antihypertensive property in a mouse model of progressive fibrosis.阿利吉仑除降压作用以外对进行性纤维化小鼠模型的肾脏保护作用。
Am J Hypertens. 2011 Mar;24(3):355-61. doi: 10.1038/ajh.2010.231. Epub 2010 Dec 2.
7
A randomized double-blind trial of enalapril in older patients with heart failure and preserved ejection fraction: effects on exercise tolerance and arterial distensibility.一项依那普利治疗老年心力衰竭和射血分数保留患者的随机双盲试验：对运动耐量和动脉可扩张性的影响。
Circ Heart Fail. 2010 Jul;3(4):477-85. doi: 10.1161/CIRCHEARTFAILURE.109.898916. Epub 2010 Jun 1.
8
Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure.口服直接肾素抑制剂阿利吉仑对有症状心力衰竭患者的影响。
Circ Heart Fail. 2008 May;1(1):17-24. doi: 10.1161/CIRCHEARTFAILURE.107.740704.
9
Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial.慢性心力衰竭患者运动训练的疗效与安全性：HF-ACTION随机对照试验
JAMA. 2009 Apr 8;301(14):1439-50. doi: 10.1001/jama.2009.454.
10
Evaluation of the performance and concordance of clinical questionnaires for the diagnosis of heart failure in primary care.基层医疗中用于心力衰竭诊断的临床问卷的性能及一致性评估。
Eur J Heart Fail. 2004 Oct;6(6):813-20, 821-2. doi: 10.1016/j.ejheart.2004.08.003.
Zotero 插件