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阿利吉仑对射血分数保留的老年心力衰竭患者运动能力的影响：一项随机、安慰剂对照、双盲试验。

The effect of Aliskiren on exercise capacity in older patients with heart failure and preserved ejection fraction: A randomized, placebo-controlled, double-blind trial.

机构信息

Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC.

Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC.

出版信息

Am Heart J. 2018 Jul;201:164-167. doi: 10.1016/j.ahj.2018.03.019. Epub 2018 Apr 4.

DOI:10.1016/j.ahj.2018.03.019
PMID:29910050
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7707854/
Abstract

In older patients (70 ± 7 years) with chronic well-compensated heart failure with preserved ejection and controlled blood pressure, 6 months treatment with aliskiren (direct renin inhibitor) showed non-significant trends for modest improvements in peak exercise oxygen consumption (14.9 ± 0.2 mL kg min versus 14.4 ± 0.2 mL kg min; P = .10, trend) and ventilatory anaerobic threshold (888 ± 19 mL/min versus 841 ± 18 mL/min; P = .08).

摘要

在慢性代偿性射血分数保留心力衰竭且血压得到控制的老年患者（70 ± 7 岁）中，使用阿利吉仑（直接肾素抑制剂）治疗 6 个月，峰值运动耗氧量（14.9 ± 0.2 mL·kg-1·min-1 与 14.4 ± 0.2 mL·kg-1·min-1；P =.10，趋势）和通气无氧阈（888 ± 19 mL/min 与 841 ± 18 mL/min；P =.08）有适度改善的非显著趋势。

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本文引用的文献

1
Aliskiren, Enalapril, or Aliskiren and Enalapril in Heart Failure.阿利吉仑、依那普利或阿利吉仑和依那普利治疗心力衰竭。
N Engl J Med. 2016 Apr 21;374(16):1521-32. doi: 10.1056/NEJMoa1514859. Epub 2016 Apr 4.
2
Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.热量限制或有氧运动训练对射血分数保留的肥胖老年心力衰竭患者峰值耗氧量和生活质量的影响：一项随机临床试验。
JAMA. 2016 Jan 5;315(1):36-46. doi: 10.1001/jama.2015.17346.
3
Effect of aliskiren on postdischarge mortality and heart failure readmissions among patients hospitalized for heart failure: the ASTRONAUT randomized trial.阿利吉仑对心力衰竭住院患者出院后死亡率和心力衰竭再入院的影响：ASTRONAUT 随机试验。
JAMA. 2013 Mar 20;309(11):1125-35. doi: 10.1001/jama.2013.1954.
4
Reliability of peak exercise testing in patients with heart failure with preserved ejection fraction.射血分数保留的心力衰竭患者运动峰值测试的可靠性。
Am J Cardiol. 2012 Dec 15;110(12):1809-13. doi: 10.1016/j.amjcard.2012.08.015. Epub 2012 Sep 13.
5
Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction.直接肾素抑制剂阿利吉仑对伴收缩功能障碍的心肌梗死后左心室重构的影响。
Eur Heart J. 2011 May;32(10):1227-34. doi: 10.1093/eurheartj/ehq522. Epub 2011 Feb 10.
6
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7
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8
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Circ Heart Fail. 2008 May;1(1):17-24. doi: 10.1161/CIRCHEARTFAILURE.107.740704.
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Eur J Heart Fail. 2004 Oct;6(6):813-20, 821-2. doi: 10.1016/j.ejheart.2004.08.003.