Pneumology Service and Thoracic Surgery, University Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
Pneumology Service and Thoracic Surgery, University Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
Pulmonology. 2018 Sep-Oct;24(5):275-279. doi: 10.1016/j.pulmoe.2018.04.007. Epub 2018 Jun 15.
Exercise-induced desaturation in chronic obstructive pulmonary disease (COPD) frequently has prognostic implications. Desaturation within the first minute of the walk 6-minute walk test will probably also occur in daily life activities and translate into hypoxaemic respiratory failure at rest in later years. This study aimed at comparing these patients with those who desaturate after the first minute and determine potential markers.
We conducted a cross-sectional, retrospective study collecting data on respiratory function tests, cardiovascular comorbidity, body mass index, pack-year index, 6-minute walk test outcomes, BODE index, and Charlson comorbidity index. Patients who desaturated during the first minute of the test were referred to as early desaturators compared to the non-early ones.
We observed a higher mean body mass index in early desaturating patients, and an inverse relation as to the body mass index categories <25, 25-29, and ≥30. Early desaturators had a lower FEV/FVC index. The mean distance walked in the test was shorter in early than in non-early desaturators, and they desaturated more deeply.
Overweight and obesity, as determined by body mass index, seem to behave like markers for early desaturation. This simple anthropometric measure might indicate point to potential early desaturation in COPD patients.
慢性阻塞性肺疾病（COPD）患者运动诱导的血氧饱和度下降通常具有预后意义。在 6 分钟步行试验的第 1 分钟内发生的血氧饱和度下降也可能会在日常生活活动中发生，并在以后的几年中转化为静息时的低氧呼吸衰竭。本研究旨在比较这些在第 1 分钟内发生血氧饱和度下降的患者和那些在第 1 分钟后发生血氧饱和度下降的患者，并确定潜在的标志物。
我们进行了一项横断面、回顾性研究，收集了呼吸功能测试、心血管合并症、体重指数、吸烟指数、6 分钟步行测试结果、BODE 指数和 Charlson 合并症指数的数据。在测试的第 1 分钟内发生血氧饱和度下降的患者被称为早期血氧饱和度下降者，与非早期血氧饱和度下降者相比。
我们观察到早期血氧饱和度下降者的平均体重指数较高，并且随着体重指数<25、25-29 和≥30 的类别呈反比关系。早期血氧饱和度下降者的 FEV/FVC 指数较低。与非早期血氧饱和度下降者相比，早期血氧饱和度下降者在测试中行走的平均距离较短，并且他们的血氧饱和度下降更深。
体重指数所确定的超重和肥胖似乎是早期血氧饱和度下降的标志物。这种简单的人体测量指标可能表明 COPD 患者存在潜在的早期血氧饱和度下降。
