Matsushima T, Maekubo H, Yoshida T, Taneda H, Yoshida J, Miyazaki T, Okada F
Horm Metab Res. 1985 Jun;17(6):306-7. doi: 10.1055/s-2007-1013525.
To clarify the factor(s) responsible for changes in the plasma cyclic GMP concentration in liver diseases, we measured the plasma levels of cyclic GMP, along with cyclic AMP, in various clinical stages of chronic liver diseases and acute hepatitis. The level of cyclic GMP was found to increase significantly in the early stage of acute hepatitis, in the decompensated stage of liver cirrhosis, and in malignant diseases. In the former two states, it is postulated that decreased hepatic mass is responsible for the changes in the plasma cyclic GMP concentration. The retention rate of indocyanin green (ICGR15) was highly correlated with the plasma cyclic GMP level. The result suggests that the determination of plasma cyclic GMP is useful as an index of the reserve function of the liver in disease states.
为阐明肝脏疾病中血浆环磷酸鸟苷（cGMP）浓度变化的相关因素，我们检测了慢性肝病和急性肝炎各临床阶段血浆中cGMP以及环磷酸腺苷（cAMP）的水平。结果发现，急性肝炎早期、肝硬化失代偿期及恶性疾病时，血浆cGMP水平显著升高。在前两种情况下，推测肝脏质量减少是血浆cGMP浓度变化的原因。吲哚菁绿滞留率（ICGR15）与血浆cGMP水平高度相关。该结果表明，测定血浆cGMP可作为疾病状态下肝脏储备功能的一个指标。
