Iagoda A V, Topchieva G Iu, Geĭvandova N I, Markova I V
Klin Med (Mosk). 1993;71(3):51-5.
Pg E, F2 alpha and F1 alpha, protein-bound plasmic oxyproline (PBPO) as well as 24-h oxyprolinuria (OPU) were measured in 119 patients suffering from various forms of chronic hepatic diseases. Composition of cellular infiltrates in histological specimens was assessed quantitatively for chronic hepatitis patients. Hepatic levels of Pg E, OPU and PBPO were elevated in all the patients, whereas PgF2 alpha and 6-keto-PgF1 alpha values were similar to controls. There were relationships between PBPO and OPU, PgE and 6-keto-PgF1 alpha. Unlike patients with active hepatitis and hepatic cirrhosis, those with chronic persistent hepatitis demonstrated a direct correlation between cellular infiltrate fibroblasts and PgE, PgF2 alpha; between PgF2 alpha and Kupffer's cells content. Inverse relationship occurred between PgE and free hepatic macrophages. In response to prostenon (PGE2) moderate PBPO decline went in line with elevation of cAMP/cGMP. A significant increase of PBPO during introduction of ensaprost-F (PgF2 alpha) did not result in changes in cyclic nucleotides. Prostenon treatment decreased PBPO under no shifts in OPU. A regulatory role of PgE is suggested in collagen metabolism stabilization. Prostenon is proposed for therapeutic use to inhibit sclerotic processes in liver impairment.
在119例患有各种慢性肝病的患者中，检测了前列腺素E（Pg E）、F2α和F1α、蛋白结合血浆羟脯氨酸（PBPO）以及24小时羟脯氨酸尿（OPU）。对慢性肝炎患者的组织学标本中的细胞浸润成分进行了定量评估。所有患者的肝脏Pg E、OPU和PBPO水平均升高，而PgF2α和6-酮-PgF1α值与对照组相似。PBPO与OPU、PgE与6-酮-PgF1α之间存在相关性。与活动性肝炎和肝硬化患者不同，慢性持续性肝炎患者的细胞浸润成纤维细胞与PgE、PgF2α之间呈直接相关；PgF2α与库普弗细胞含量之间也呈直接相关。PgE与游离肝巨噬细胞之间呈负相关。对前列腺素（PGE2）的反应中，PBPO适度下降与cAMP/cGMP升高一致。引入恩沙前列素-F（PgF2α）期间PBPO显著增加，但未导致环核苷酸变化。前列腺素治疗可降低PBPO，但OPU无变化。提示PgE在胶原代谢稳定中起调节作用。建议将前列腺素用于治疗，以抑制肝损伤中的硬化过程。
