Wagenseil Jessica E
Dept. of Mechanical Engineering and Materials Science, Washington University, St. Louis, MO.
Curr Opin Biomed Eng. 2018 Mar;5:50-57. doi: 10.1016/j.cobme.2018.01.002. Epub 2018 Feb 7.
Most thoracic aortic aneurysms (TAAs) occur in the ascending aorta. This review focuses on the unique bio-chemo-mechanical environment that makes the ascending aorta susceptible to TAA. The environment includes solid mechanics, fluid mechanics, cell phenotype, and extracellular matrix composition. Advances in solid mechanics include quantification of biaxial deformation and complex failure behavior of the TAA wall. Advances in fluid mechanics include imaging and modeling of hemodynamics that may lead to TAA formation. For cell phenotype, studies demonstrate changes in cell contractility that may serve to sense mechanical changes and transduce chemical signals. Studies on matrix defects highlight the multi-factorial nature of the disease. We conclude that future work should integrate the effects of bio-chemo-mechanical factors for improved TAA treatment.
大多数胸主动脉瘤（TAA）发生在升主动脉。本综述聚焦于使升主动脉易患TAA的独特生物 - 化学 - 力学环境。该环境包括固体力学、流体力学、细胞表型和细胞外基质组成。固体力学方面的进展包括对TAA壁双轴变形和复杂破坏行为的量化。流体力学方面的进展包括对可能导致TAA形成的血流动力学的成像和建模。对于细胞表型，研究表明细胞收缩性的变化可能有助于感知机械变化并传导化学信号。对基质缺陷的研究突出了该疾病的多因素性质。我们得出结论，未来的工作应整合生物 - 化学 - 力学因素的影响，以改善TAA的治疗。
