营养对2型小鼠肝炎病毒免疫力和易感性的影响。
Influences of nutrition on immunity and susceptibility to mouse hepatitis virus type 2.
作者信息
Esa A H, Reissig M
出版信息
Immunology. 1985 Jul;55(3):539-45.
Resistance to mouse hepatitis virus (MHV) in C3H mice is a genetic trait which appears 3-4 weeks after birth. However, when these animals were weaned on a low protein diet (8% casein), they remained susceptible to MHV-2 infection until they reached 8-9 weeks of age. During this period, the protein-restricted C3H mice were as susceptible to MHV-2 as the genetically susceptible congenic C3Hss strain. The delay in the emergence of resistance in the protein-restricted mice could be corrected by injecting these animals with spleen cells from 6-week-old C3H mice. Thymocytes from normal C3H mice, and splenocytes and thymocytes from protein-restricted C3H mice, were not protective. However, spleen cells from the protein-restricted mice were more responsive to phytohaemagglutinin, lipopolysaccharide and concanavalin A than spleen cells from normal C3H. The enhanced lymphoproliferative response in spleen cells from protein-restricted mice was abrogated by the addition of plastic-adherent cells obtained from normal C3H spleens. Spleen cells from protein-restricted and from genetically susceptible C3Hss mice also possessed more spontaneous cytotoxicity against MHV-infected 3T3 fibroblasts.
C3H小鼠对小鼠肝炎病毒（MHV）的抗性是一种出生后3 - 4周出现的遗传特性。然而，当这些动物以低蛋白饮食（8%酪蛋白）断奶时，它们在8 - 9周龄之前一直易受MHV - 2感染。在此期间，蛋白质限制的C3H小鼠对MHV - 2的易感性与基因易感的同基因C3Hss品系相同。给蛋白质限制的小鼠注射6周龄C3H小鼠的脾细胞可以纠正其抗性出现的延迟。正常C3H小鼠的胸腺细胞以及蛋白质限制的C3H小鼠的脾细胞和胸腺细胞均无保护作用。然而，蛋白质限制小鼠的脾细胞对植物血凝素、脂多糖和伴刀豆球蛋白A的反应比正常C3H小鼠的脾细胞更强。添加从正常C3H脾脏获得的塑料贴壁细胞可消除蛋白质限制小鼠脾细胞中增强的淋巴细胞增殖反应。蛋白质限制小鼠和基因易感的C3Hss小鼠的脾细胞对MHV感染的3T3成纤维细胞也具有更强的自发细胞毒性。
Zotero 插件