Smith R A, Esa A, Stiff M
Infect Immun. 1982 Apr;36(1):271-6. doi: 10.1128/iai.36.1.271-276.1982.
Protective host immunity and delayed hypersensitivity were transferred to nonimmune ICR and C3H/HeJ mice with transfer factor prepared from the splenic lymphocytes of ICR Swiss mice immune to Salmonella typhimurium. Only mice injected with the "immune" dialysate exhibited significant footpad swelling (P less than 0.01) to a spent medium antigen of S. typhimurium, but not Listeria monocytogenes. Host survival to a lethal Salmonella challenge infection was seen only in transfer factor-injected mice. Also, these challenged animals had fewer numbers of bacteria present in their spleens (P less than 0.01) than did challenged mice previously injected with either control dialysates or commercial endotoxin. Neither the Salmonella antigens nor endotoxin present in the sterile transfer factor preparation was responsible for the transfer of host protection and delayed hypersensitivity, since none of the control dialysates resulted in any positive responses when injected into either the ICR Swiss or endotoxin-resistant C3H/HeJ mice.
用从对鼠伤寒沙门氏菌免疫的ICR瑞士小鼠脾淋巴细胞制备的转移因子，将保护性宿主免疫和迟发型超敏反应转移至无免疫力的ICR和C3H/HeJ小鼠。只有注射了“免疫”透析液的小鼠对鼠伤寒沙门氏菌的用过的培养基抗原表现出显著的足垫肿胀（P小于0.01），但对单核细胞增生李斯特菌无此反应。仅在注射转移因子的小鼠中观察到宿主对致死性沙门氏菌攻击感染的存活情况。此外，与先前注射对照透析液或商业内毒素的攻击小鼠相比，这些受攻击动物脾脏中的细菌数量更少（P小于0.01）。无菌转移因子制剂中存在的沙门氏菌抗原和内毒素均与宿主保护和迟发型超敏反应的转移无关，因为当将任何对照透析液注射到ICR瑞士小鼠或对内毒素有抗性的C3H/HeJ小鼠中时，均未产生任何阳性反应。
