Blum K, Jacobs W, Modestino E J, DiNubile N, Baron D, McLaughlin T, Siwicki D, Elman I, Moran M, Braverman E R, Thanos P K, Badgaiyan R D
Department of Psychiatry and Behavioral Sciences, Keck Medicine University of Southern California, USA.
Division of Applied Clinical Research & Education, Dominion Diagnostics, USA.
SEJ Surg Pain. 2018 Oct 4;1(1):1-11.
The United States are amid an opioid overdose epidemic; we are challenged to provide non-addicting/non-pharmacological alternatives to assist in pain attenuation. There are proven strategies available to manage chronic pain effectively without opioids. Utilization review providers for insurance companies often ignore medicine based scientific peer-reviewed studies that warn against the chronic use of opioid medications, as well as the lack of evidence to support long-term use of opioids for pain. This paradigm must change if we are to indeed change the drug-embracing culture in American chronic pain management. A barrier to treatment is pushback on the part of insurance companies especially as it relates to fighting against pain relief alternatives compared to classical analgesic agents. Pain specialists in the U.S., are compelled to find alternative solutions to help pain victims without promoting unwanted tolerance to analgesics and subsequent biological induction of the "addictive brain." It is noteworthy that reward center of the brain plays a crucial role in the modulation of nociception, and that adaptations in dopaminergic circuitry may affect several sensory and affective components of chronic pain syndromes. Possibly knowing a patient's genetic addiction risk score (GARS™) could eliminate guessing as it relates to becoming addicted.
美国正处于阿片类药物过量流行之中;我们面临着提供非成瘾性/非药物替代方案以帮助减轻疼痛的挑战。有一些经过验证的策略可在不使用阿片类药物的情况下有效管理慢性疼痛。保险公司的利用审查机构常常忽视基于医学的、经过同行评审的科学研究,这些研究警告不要长期使用阿片类药物,以及缺乏支持长期使用阿片类药物治疗疼痛的证据。如果我们要真正改变美国慢性疼痛管理中对药物的接受文化,这种模式必须改变。治疗的一个障碍是保险公司的抵制,特别是在与传统镇痛药相比对抗疼痛缓解替代方案方面。美国的疼痛专家不得不寻找替代解决方案,以帮助疼痛患者,同时又不促进对镇痛药产生不必要的耐受性以及随后对“成瘾性大脑”的生物学诱导。值得注意的是,大脑的奖赏中枢在伤害感受的调节中起着关键作用,并且多巴胺能神经回路的适应性变化可能会影响慢性疼痛综合征的几个感觉和情感成分。可能了解患者的遗传成瘾风险评分(GARS™)可以消除与成瘾相关的猜测。