Blum Kenneth, Downs B W, Dushaj Kristina, Li Mona, Braverman Eric R, Fried Lyle, Waite Roger, Demotrovics Zsolt, Badgaiyan Rajendra D
Department of Psychiatry & McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL, USA; Departments of Psychiatry & Behavioral Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA; Department of Clinical Neurology, PATH Foundation NY, New York, NY, USA; Human Integrated Services Unit, University of Vermont Centre for Clinical & Translational Science, College of Medicine, Burlington, VT, USA; Division of Addiction Services, Dominion Diagnostics, LLC., North Kingstown, RI, USA; Division of Neuroscience-based Therapy, Summit Estate Recovery Center, Los Gatos, CA, USA; The Shores Treatment & Recovery, Port Saint Lucie, FL, USA; Department of Precision Medicine, IGENE, LLC., Austin, TX, USA; Division of Nutrigenomics, LaVitaRDS, Draper, UT, USA; Institute of Psychology, Eötvös Loránd University Budapest, HUNGARY.
Victory Nutrition International, Lederoch, PA, USA.
Precis Med (Bangalore). 2016;1(1):18-33. Epub 2016 Aug 1.
DNA Customization of nutraceutical products is here. In the truest sense, "Gene Guided Precision Nutrition" and KB220 variants (a complex mixture of amino-acids, trace metals, and herbals) are the pioneers and standard-bearers for a state of the art DNA customization. Findings by both, Kenneth Blum, Ph.D. and Ernest Noble, Ph.D. concerning the role of genes in shaping cravings and pleasure- seeking, opened the doors to comprehension of how genetics control our actions and effect our mental and physical health. Moreover, technology that is related to KB220 variants in order to reduce or eradicate excessive cravings by influencing gene expression is a cornerstone in the pioneering of the practical applications of nutrigenomics. Continuing discoveries have been an important catalyst for the evolution, expansion, and scientific recognition of the significance of nutrigenomics and its remarkable contributions to human health. Neuro-Nutrigenomics is now a very important field of scientific investigation that offers great promise to improving the human condition. In the forefront is the development of the Genetic Addiction Risk Score (GARS), which unlike 23andMe, has predictive value for the severity of drug and alcohol abuse as well as other non-substance related addictive behaviors. While customization of neuronutrients has not yet been commercialized, there is emerging evidence that in the future, the concept will be developed and could have a significant impact in addiction medicine.
营养保健品的DNA定制时代已经来临。从最真实的意义上讲，“基因引导精准营养”以及KB220变体（一种氨基酸、微量金属和草药的复杂混合物）是先进DNA定制技术的先驱和旗手。肯尼斯·布卢姆博士和欧内斯特·诺布尔博士关于基因在塑造渴望和寻求愉悦方面作用的研究结果，为理解基因如何控制我们的行为以及影响我们的身心健康打开了大门。此外，与KB220变体相关的技术，即通过影响基因表达来减少或消除过度渴望，是营养基因组学实际应用开拓的基石。不断的发现一直是营养基因组学发展、扩展及其对人类健康重大贡献获得科学认可的重要催化剂。神经营养基因组学如今是一个非常重要的科学研究领域，有望极大地改善人类状况。处于前沿的是遗传成瘾风险评分（GARS）的开发，与23andMe不同，它对药物和酒精滥用的严重程度以及其他与物质无关的成瘾行为具有预测价值。虽然神经营养素的定制尚未商业化，但越来越多的证据表明，未来这个概念将会得到发展，并可能在成瘾医学领域产生重大影响。
