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New 5'-nucleotidase inhibitors, melanocidin A and melanocidin B. I. Taxonomy, fermentation, isolation and biological properties.

作者信息

Ogawara H, Uchino K, Akiyama T, Watanabe S

出版信息

J Antibiot (Tokyo). 1985 May;38(5):587-91. doi: 10.7164/antibiotics.38.587.

DOI:10.7164/antibiotics.38.587
PMID:2991179
Abstract

New 5'-nucleotidase inhibitors named melanocidins A and B were produced by Nocardioides sp. 1681 J. They were isolated from fermentation broth by trichloracetic acid extraction, ethanol precipitation and CM-cellulose and DEAE-cellulose column chromatography. They inhibited 5'-nucleotidase activity from snake venom but not from rat liver membrane at 200 micrograms/ml. They also show antitumor activity against melanoma B16.

摘要

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