Uchino K, Ogawara H, Akiyama T, Watanabe S, Fukuchi A
J Antibiot (Tokyo). 1986 May;39(5):682-7. doi: 10.7164/antibiotics.39.682.
Nucleoticidin and melanocidins A and B exhibited potent inhibitory activity against 5'-nucleotidases from rat liver membrane and snake venom. Nucleoticidin retarded growth of Sarcoma 180 solid tumor, and melanocidins A and B prolonged the survival period of mice bearing B16 melanoma. These inhibitors enhanced phagocytic activity, interleukin-1 production and superoxide-generating activity of murine peritoneal macrophages. The tumor necrosis factor was also induced by the inhibitors. These results suggested that 5'-nucleotidase inhibitors inhibit tumor growth by modification of the immune system.
核苷酸菌素以及黑素杀菌素A和B对大鼠肝膜和蛇毒中的5'-核苷酸酶表现出强效抑制活性。核苷酸菌素抑制肉瘤180实体瘤的生长，黑素杀菌素A和B延长了荷B16黑色素瘤小鼠的生存期。这些抑制剂增强了小鼠腹腔巨噬细胞的吞噬活性、白细胞介素-1生成活性和超氧化物生成活性。这些抑制剂还诱导了肿瘤坏死因子。这些结果表明，5'-核苷酸酶抑制剂通过调节免疫系统来抑制肿瘤生长。
