Angle Orthod. 2018 Nov;88(6):806-811. doi: 10.2319/111317-773.1. Epub 2018 Jun 18.
: To examine possible changes in the levels of salivary antioxidants, C-reactive protein (CRP), cortisol, pH, proteins, and blood in patients treated with fixed orthodontic appliances.
: Salivary samples from 21 orthodontic patients who met specific inclusion criteria were collected before the beginning of orthodontic treatment (T0; baseline), 1 hour after bonding (T1), and 4-6 weeks after bonding (T2). Oxidant-scavenging ability (OSA) was quantified using a luminol-dependent chemiluminescence assay. Cortisol and CRP levels were measured using immunoassay kits. pH levels and presence of proteins and blood in the samples were quantified using strip-based tests.
: A significant decrease in salivary pH was observed after bonding ( P = .013). An increase in oxidant-scavenging abilities during orthodontic treatment was detected, but the change was not statistically significant. Cortisol and CRP levels slightly increased after bonding, but the difference was small without statistical significance. Changes in the presence of proteins and blood were also insignificant.
: Exposure to fixed orthodontic appliances did not show a significant effect on salivary parameters related to inflammation or stress, with the exception of a significant but transient pH decrease after bonding.
研究固定正畸矫治器治疗患者的唾液抗氧化剂、C 反应蛋白（CRP）、皮质醇、pH 值、蛋白质和血液水平的可能变化。
收集了 21 名符合特定纳入标准的正畸患者的唾液样本，在正畸治疗开始前（T0；基线）、粘结后 1 小时（T1）和粘结后 4-6 周（T2）进行采集。使用发光依赖性化学发光测定法定量测定抗氧化能力（OSA）。使用免疫测定试剂盒测量皮质醇和 CRP 水平。使用条带测试定量测定样品中的 pH 值以及蛋白质和血液的存在。
粘结后唾液 pH 值显著下降（P=0.013）。在正畸治疗过程中检测到抗氧化能力的增加，但变化无统计学意义。粘结后皮质醇和 CRP 水平略有升高，但差异较小，无统计学意义。蛋白质和血液的存在变化也不显著。
固定正畸矫治器的暴露对与炎症或压力相关的唾液参数没有明显影响，除了粘结后 pH 值有显著但短暂的下降。
